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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Early-life risperidone administration alters maternal-offspring interactions and juvenile play fighting
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Early-life risperidone administration alters maternal-offspring interactions and juvenile play fighting

机译：早期使用利培酮治疗可改变母婴互动和青少年打斗

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Risperidone is an antipsychotic drug that is approved for use in childhood psychiatric disorders such as autism. One concern regarding the use of this drug in pediatric populations is that it may interfere with social interactions that serve to nurture brain development. This study used rats to assess the impact of risperidone administration on maternal-offspring interactions and juvenile play fighting between cage mates. Mixed-sex litters received daily subcutaneous injections of vehicle or 1.0 or 3.0 mg/kg of risperidone between postnatal days (PNDs) 14-42. Rats were weaned and housed three per cage on PND 21. In observations made between PNDs 14-17, risperidone significantly suppressed several aspects of maternal-offspring interactions at 1-hour post-injection. At 23 h post-injection, pups administered risperidone had lower activity scores and made fewer non-nursing contacts with their moms. In observations of play-fighting behavior made once a week between PNDs 22-42, risperidone profoundly decreased many forms of social interaction at 1 h post-injection. At 23 h post-injection, rats administered risperidone made more non-social contacts with their cage mates, but engaged in less social grooming. Risperidone administration to rats at ages analogous to early childhood through adolescence in humans produces a pattern of abnormal social interactions across the day that could impact how such interactions influence brain development
机译：利培酮是一种抗精神病药，已被批准用于儿童精神病（例如自闭症）。有关在小儿人群中使用这种药物的一个担忧是，它可能会干扰促进大脑发育的社交互动。这项研究使用大鼠评估了利培酮给药对笼子伴侣之间母婴相互作用和青少年游戏的影响。在产后几天（PNDs）之间，混合性别的小窝每天接受皮下注射媒介物或1.0或3.0 mg / kg利培酮的皮下注射（PNDs）14-42。给大鼠断奶并在PND 21上每笼饲养三只。在PND 14-17之间进行的观察中，利培酮在注射后1小时显着抑制了母婴相互作用的几个方面。注射后23小时，服用利培酮的幼犬活动评分较低，与母亲的非护理接触较少。在每周一次的PND 22-42之间进行的打架行为观察中，利培酮在注射后1 h大大减少了许多形式的社交互动。注射后23小时，服用利培酮的大鼠与其笼伴侣进行了更多的非社交接触，但较少进行社交修饰。利培酮在人类中的青春期类似于幼年时对大鼠的给药会产生全天异常的社交互动模式，这可能会影响这种互动方式对大脑发育的影响

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