• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >L-Menthone confers antidepressant-like effects in an unpredictable chronic mild stress mouse model via NLRP3 inflammasome-mediated inflammatory cytokines and central neurotransmitters
【24h】

L-Menthone confers antidepressant-like effects in an unpredictable chronic mild stress mouse model via NLRP3 inflammasome-mediated inflammatory cytokines and central neurotransmitters

机译：L-Menthone通过NLRP3炎性体介导的炎性细胞因子和中枢神经递质在不可预测的慢性轻度应激小鼠模型中赋予抗抑郁样作用

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

L-Menthone (MTN) is a Chinese old remedy extracted from the genus Mentha. It has been widely used as a cooling agent and a counterirritant for pain relief, although its antidepressant-like effects have not yet been reported. The present study was designed to investigate whether MTN confers an antidepressant-like effect in mice exposed to unpredictable chronic mild stress (UCMS) and to explore its potential mechanisms. The effects of MTN on mouse behavioral changes were investigated in our study. We determined the levels of the nucleotide binding, oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, inflammatory cytokines and neurotransmitters in the hippocampus of mice. Behavioral tests, including the sucrose preference test (SPT), open field test (OFT), forced swimming test (FST) and tail suspension test (TST) revealed that MTN (15 and 30 mg/kg) treatments for 3 weeks alleviated the depression symptoms of UCMS in mice. Mice receiving MTN treatments exhibited reduced levels of NLRP3 and caspase-1. Moreover, MTN treatments reversed the UCMS-induced alterations in the concentrations of neurotransmitter norepinephrine (NE) and serotonin (5-HT) and inhibited the expression of pro-inflammatory cytolcines (PLC) interleukin (1)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha in the hippocampus of mice. Taken together, our findings suggested that MTN may play a potential antidepressant-like role in the UCMS mouse model by regulating the NLRP3 inflammasome and mediating inflammatory cytokines and central neurotransmitters, which together provide insight towards the development of novel therapeutic treatments for depression. (C) 2015 Elsevier Inc. All rights reserved.
机译：L-Menthone（MTN）是从薄荷（Mentha）属中提取的一种中国古老药物。尽管尚未报道其抗抑郁样作用，但它已被广泛用作清凉剂和镇痛药。本研究旨在调查MTN是否在暴露于不可预测的慢性轻度应激（UCMS）的小鼠中赋予抗抑郁样作用，并探讨其潜在机制。在我们的研究中研究了MTN对小鼠行为改变的影响。我们确定了小鼠海马中的核苷酸结合水平，寡聚化域样受体家族，含吡啶域的3（NLRP3）炎性小体，炎性细胞因子和神经递质的水平。行为测试，包括蔗糖偏爱测试（SPT），露天测试（OFT），强迫游泳测试（FST）和尾部悬吊测试（TST）显示，MTN（15和30 mg / kg）治疗3周可缓解抑郁症小鼠UCMS症状。接受MTN处理的小鼠的NLRP3和caspase-1含量降低。此外，MTN治疗可逆转UCMS诱导的神经递质去甲肾上腺素（NE）和5-羟色胺（5-HT）浓度的变化，并抑制促炎性细胞因子（PLC）白介素（1）-1 beta，IL-6，和小鼠海马中的肿瘤坏死因子（TNF）-α。综上所述，我们的发现表明，MTN可能通过调节NLRP3炎性小体并介导炎性细胞因子和中枢神经递质而在UCMS小鼠模型中发挥潜在的抗抑郁药样作用，共同为开发新型的抑郁症治疗方法提供了见识。 （C）2015 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号