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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Quetiapine and repetitive transcranial magnetic stimulation ameliorate depression-like behaviors and up-regulate the proliferation of hippocampal-derived neural stem cells in a rat model of depression: The involvement of the BDNF/ERK signal pathway
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Quetiapine and repetitive transcranial magnetic stimulation ameliorate depression-like behaviors and up-regulate the proliferation of hippocampal-derived neural stem cells in a rat model of depression: The involvement of the BDNF/ERK signal pathway

机译：喹硫平和反复经颅磁刺激改善抑郁症大鼠模型中的抑郁样行为并上调海马源性神经干细胞的增殖：BDNF / ERK信号通路的参与

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Quetiapine (QUE) and repetitive transcranial magnetic stimulation (rTMS) have been considered to be possible monotherapies for depression or adjunctive therapies for the treatment of the resistant depression, but the underlying mechanisms remain unclear. The present study aimed to assess the effects of combined QUE and rTMS treatment on depressive-like behaviors, hippocampal proliferation, and the in vivo and in vitro expressions of phosphorylated extracellular signal-regulated protein kinase (pERK1/2) and brain-derived neurotrophic factor (BDNF) in male Sprague-Dawley rats. The administration of QUE and rTMS was determined not only to reverse the depressive-like behaviors of rats exposed to chronic unpredictable stress (CUS) but also to restore the protein expressions of pERK1/2 and BDNF and cell proliferation in the hippocampus. Additionally, QUE and rTMS promoted the proliferation and increased the expression of pERK1/2 and BDNF in hippocampal-derived neural stem cells (NSCs), and these effects were abolished by U0126. Taken together, these results suggest that the antidepressive-like effects of QUE and rTMS might be related to the activation of the BDNF/ERK signaling pathway and the up-regulation of cell proliferation in the hippocampus. (C) 2015 Elsevier Inc. All rights reserved.
机译：喹硫平（QUE）和重复经颅磁刺激（rTMS）被认为可能是抑郁症的单一疗法或用于治疗耐药性抑郁症的辅助疗法，但其潜在机制尚不清楚。本研究旨在评估QUE和rTMS联合治疗对抑郁样行为，海马增殖以及磷酸化细胞外信号调节蛋白激酶（pERK1 / 2）和脑源性神经营养因子的体内和体外表达的影响（BDNF）在雄性Sprague-Dawley大鼠中。确定施用QUE和rTMS不仅可以逆转暴露于慢性不可预测压力（CUS）的大鼠的抑郁样行为，还可以恢复海马pERK1 / 2和BDNF的蛋白表达以及细胞增殖。此外，QUE和rTMS促进了海马源性神经干细胞（NSC）的增殖并增加了pERK1 / 2和BDNF的表达，U0126取消了这些作用。两者合计，这些结果表明，QUE和rTMS的抗抑郁样作用可能与BDNF / ERK信号通路的激活和海马细胞增殖的上调有关。 （C）2015 Elsevier Inc.保留所有权利。

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