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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Ameliorating effect of p-hydroxybenzyl alcohol on cycloheximide-induced impairment of passive avoidance response in rats: interactions with compounds acting at 5-HT1A and 5-HT2 receptors.
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Ameliorating effect of p-hydroxybenzyl alcohol on cycloheximide-induced impairment of passive avoidance response in rats: interactions with compounds acting at 5-HT1A and 5-HT2 receptors.

机译：对羟基苯甲醇对环己酰亚胺对大鼠被动回避反应的损害的改善作用：与作用于5-HT1A和5-HT2受体的化合物的相互作用。

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摘要

The effect of p-hydroxybenzyl alcohol (HBA) on cycloheximide (CXM)-induced impairment in the step-through passive avoidance task was investigated in rats and compared to the effect of the nootropic piracetam. HBA and piracetam significantly counteracted the CXM-induced shortening of retention latencies. The effect of HBA was a bell-shaped dose-response curve with a maximal effect of 5 mg/kg. The counteractive effect of HBA was not depressed by either scopolamine or mecamylamine. The serotonin (5-HT) releaser, p-chloroamphetamine, and presursor, 5-hydroxytryptophan, significantly antagonized the counteractive effect of HBA on the CXM-induced shortening of retention latencies. Furthermore, the counteractive effect was also inhibited by the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and the 5-HT2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane [(+/-)-DOI], but potentiated by the 5-HT1 receptor antagonist (+/-)-pindolol and the 5-HT2 receptor antagonist ritanserin. There results suggest that the beneficial effect of HBA on CXM-induced impairment is amplified by treatment with serotonergic receptor antagonists but reduced by serotonergic 5-HT1A and 5-HT2 receptor agonists, and insensitive to cholinergic manipulations.
机译：在大鼠中研究了对羟基苯甲醇（HBA）对环己酰亚胺（CXM）诱导的逐步被动回避任务中的损伤的作用，并将其与促智的吡乙酰胺的作用进行了比较。 HBA和吡乙酰胺显着抵消了CXM引起的保留潜伏期缩短。 HBA的作用是钟形的剂量反应曲线，最大作用为5 mg / kg。东pol碱或美甲胺均不能抑制HBA的反作用。血清素（5-HT）释放剂，对氯苯丙胺和前体5-羟基色氨酸显着拮抗HBA对CXM诱导的保留潜伏期缩短的反作用。此外，5-HT1A受体激动剂8-羟基-2-（二-正丙基氨基）四氢化萘（8-OH-DPAT）和5-HT2受体激动剂1-（2,5-二甲氧基-4-碘苯基）-2氨基丙烷[（+/-）-DOI]，但由5-HT1受体拮抗剂（+/-）-哌多洛尔和5-HT2受体拮抗剂利坦色林增强。结果表明，HBA对CXM诱导的损伤的有益作用通过血清素能受体拮抗剂的治疗得以增强，但由血清素能5-HT1A和5-HT2受体激动剂降低，并且对胆碱能的操作不敏感。

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