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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Opioid receptor blockade promotes weight loss and improves the display of sexual behaviors in obese Zucker female rats.
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Opioid receptor blockade promotes weight loss and improves the display of sexual behaviors in obese Zucker female rats.

机译：阿片受体阻断剂可促进肥胖的Zucker雌性大鼠减轻体重并改善性行为的表现。

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Obese Zucker female rats are hyperphagic, overweight, infertile, and hyporesponsive to the inductive effects of ovarian steroid hormones on sexual behaviors. It has been postulated that endogenous opioid activity may contribute to their obesity and reproductive dysfunction. To test this hypothesis, ovariectomized, adult obese Zucker rats were treated with the opioid receptor antagonist, naltrexone, or saline prior to measurement of steroid-induced sexual behaviors, food intake, and body weight. In estradiol benzoate (EB)-treated rats, naltrexone injection increased the display of sexual receptivity (lordosis quotient, LQ: saline, 11+/-10%; 5 mg/kg naltrexone, 54+/-15%, p < 0.05) and also elicited proceptivity (PRO), which was never observed after saline injection. In EB plus progesterone-treated animals, naltrexone administration enhanced both sexual receptivity and proceptivity (LQ: saline, 17+/-10%; 5 mg/kg naltrexone, 96+/-3%; p < 0.05; PRO: saline, 3.0+/-2.4 bouts/min; 5 mg/kg naltrexone, 45.3+/-12 bouts/min; p < 0.01). Naltrexone injection also decreased 24-h food intake (saline, 24.2+/-0.7 g; 5 mg/kg naltrexone, 17.6+/-1.2 g; p < 0.05) and weight change (saline, +7.3+/-0.8 g; 5 mg/kg naltrexone, -4.5+/-1.4 g, p < 0.01). Morphine treatment blocked these effects of naltrexone on sexual behaviors, food intake, and body weight. These data suggest that endogenous opioids contribute to hyperphagia, obesity, and behavioral hyporesponsiveness to ovarian steroid hormones in obese Zucker rats.
机译：肥胖的祖克雌性大鼠肥大，超重，不育，并且对卵巢类固醇激素对性行为的诱导作用反应不足。据推测，内源性阿片类药物活性可能导致其肥胖和生殖功能障碍。为了检验这一假设，在测量类固醇诱发的性行为，食物摄入和体重之前，先对阿片切除的成年肥胖Zucker大鼠进行阿片受体拮抗剂，纳曲酮或盐水治疗。在雌二醇苯甲酸酯（EB）治疗的大鼠中，纳曲酮注射可增加性接受能力的表现（多虫病，LQ：盐水，11 +/- 10％; 5 mg / kg纳曲酮，54 +/- 15％，p <0.05）并且还引发了注射盐水后从未观察到的感受力（PRO）。在EB加孕激素治疗的动物中，纳曲酮的给药增强了性接受性和易感性（LQ：盐水，17 +/- 10％; 5 mg / kg纳曲酮，96 +/- 3％; p <0.05; PRO：盐水，3.0 +/- 2.4 bouts / min; 5 mg / kg纳曲酮，45.3 +/- 12 bouts / min; p <0.01）。注射纳曲酮还可以减少24小时食物摄入量（盐水，24.2 +/- 0.7 g; 5 mg / kg纳曲酮，17.6 +/- 1.2 g; p <0.05）和体重变化（盐水，+7.3 +/- 0.8 g;盐水）。 5 mg / kg纳曲酮，-4.5 +/- 1.4 g，p <0.01）。吗啡治疗可以阻止纳曲酮对性行为，食物摄入和体重的影响。这些数据表明，内源性阿片类药物可导致肥胖的Zucker大鼠过度吞咽，肥胖以及对卵巢类固醇激素的行为反应不足。

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