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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effects of atypical antipsychotics and phencyclidine (PCP) on rotorod performance.
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The effects of atypical antipsychotics and phencyclidine (PCP) on rotorod performance.

机译：非典型抗精神病药和苯环利定（PCP）对旋翼机性能的影响。

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摘要

A series of six experiments were conducted to determine the effects of haloperidol, clozapine, olanzapine, and phencyclidine (PCP) on rotorod performance. Rodents were trained to walk on a rotorod to avoid a mild shock to a criterion of 20 rpm for 3 min. None of the vehicles of any of these drugs disrupted rotorod performance. Haloperidol disrupted rotorod performance at doses of 0.03, 0.1, and 0.3 mg/kg, and olanzapine disrupted rotorod performance at doses of 3.0 and 10.0 mg/kg. Clozapine produced a much milder disruption across all three doses (3.0, 10.0, and 30.0 mg/kg). PCP produced a consistent and severe disruption of rotorod performance at doses of 4.0 and 6.0 mg/kg, but not at a dose of 2.0 mg/kg. Twenty-four hours postinjection there were no residual PCP effects on rotorod performance. Coadministration of either haloperidol or olanzapine with PCP did not reverse PCP-induced disruption in rotorod performance, while clozapine produced a partial reversal at only one dose. These findings indicate that olanzapine functions similarly to classic antipsychotics with respect to their effects on locomotion and balance.
机译：进行了一系列的六个实验，以确定氟哌啶醇，氯氮平，奥氮平和苯环利定（PCP）对旋翼飞行器性能的影响。训练啮齿类动物在旋翼车上行走，以避免轻微的震动，以20 rpm的速度持续3分钟。这些药物中的任何一种都没有破坏旋翼飞行器的性能。氟哌啶醇在0.03、0.1和0.3 mg / kg的剂量下破坏了旋翼机的性能，奥氮平在3.0和10.0 mg / kg的剂量下破坏了旋翼机的性能。氯氮平在所有三种剂量（3.0、10.0和30.0 mg / kg）中产生的破坏作用要轻得多。 PCP在4.0和6.0 mg / kg的剂量下会严重破坏旋翼机的性能，但在2.0 mg / kg的剂量下则不会。注射后二十四小时，PCP对旋翼机的性能没有残留影响。氟哌啶醇或奥氮平与五氯苯酚并用不能逆转五氯苯酚对旋翼机性能的破坏，而氯氮平仅以一剂产生部分逆转。这些发现表明，奥氮平对运动和平衡的作用与经典抗精神病药相似。

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