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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The impact of the opioids fentanyl and morphine on nociception and bone destruction in a murine model of bone cancer pain.
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The impact of the opioids fentanyl and morphine on nociception and bone destruction in a murine model of bone cancer pain.

机译：阿片类药物芬太尼和吗啡对骨痛小鼠模型的伤害感受和骨破坏的影响。

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Chronic pain resulting from metastasis into skeleton of certain neoplastic diseases remains poorly understood and relatively resistant to analgesic treatment. Opioids are the principal axis in drug therapy for this type of pain, especially at the end stage of cancer. Our aim was to examine whether, fentanyl as well as morphine, two potent analgesic opioids commonly used to treat cancer pain, would inhibit pain and bone lesion-related responses in a murine model of bone cancer pain. Repeated administration of equianalgesic doses of fentanyl (0.16 mg/kg s.c. once a day) and morphine (20 mg/kg s.c. once a day) initiated at day 1 (prophylactic treatment) or at day 7 (curative treatment) after tumor cell inoculation in the femoral cavity consistently decreased bone pain symptoms and tumor growth-induced bone destruction (micro-CT bone structure parameters). Both fentanyl and morphine treatments resulted in clear antinociceptive properties as well as reductions in cancer cell-induced bone lesions. The present results demonstrate that fentanyl, and to some lesser degree morphine, has potential benefits in the treatment and development of bone cancer pain. As such, chronic administration of high doses of certain opioids like fentanyl may have clinical utility in the management of bone cancer pain.
机译：某些肿瘤疾病转移至骨骼所引起的慢性疼痛仍知之甚少，并且对止痛药具有相对的抵抗力。阿片类药物是药物治疗这类疼痛的主轴，尤其是在癌症晚期。我们的目标是检查在用于骨癌疼痛的小鼠模型中，通常用于治疗癌症疼痛的两种有效的镇痛类阿片芬太尼和吗啡是否会抑制疼痛和与骨病变相关的反应。在肿瘤细胞接种后第1天（预防性治疗）或第7天（治愈性治疗）开始重复给予等剂量的芬太尼（每天一次0.16 mg / kg sc）和吗啡（每天一次20 mg / kg sc）。股骨腔持续减少骨痛症状和肿瘤生长引起的骨破坏（微型CT骨结构参数）。芬太尼和吗啡治疗均具有明显的抗伤害感受特性，并减少了癌细胞引起的骨损伤。目前的结果表明，芬太尼和少量的吗啡在骨癌疼痛的治疗和发展中具有潜在的益处。因此，长期服用某些剂量的某些阿片类药物（如芬太尼）可能具有治疗骨癌疼痛的临床效用。

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