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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of triazolam and diazepam on learning and memory as assessed using a water maze.
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Effects of triazolam and diazepam on learning and memory as assessed using a water maze.

机译：用水迷宫评估三唑仑和地西epa对学习和记忆的影响。

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摘要

One of the reported adverse side effects of the frequently prescribed benzodiazepines diazepam (Valium) and triazolam (Halcion) is an impairment of anterograde memory in humans. The experiments described in this article compared the effects of triazolam and diazepam on performance in a water maze task that is sensitive to drugs that affect learning and memory. The water maze utilized is a traditional type of maze with alleyways and door choices, unlike the Morris open water maze. Time required to find an out-of-the-water platform and errors committed during the swim are used as performance measures. Rats were tested on a previously learned maze configuration and on the acquisition of new maze configurations. Neither diazepam (0.25, 1.0, or 2.0 mg/kg) nor triazolam (0.05, 0.2, or 0.3 mg/kg) injected 30 min prior to testing on the previously learned maze affected swim time or errors committed. Administration of diazepam (0.5, 1.0, or 2.0 mg/kg, IP) prior to daily training on three different new maze configurations did not affect swim time, but did increase swim errors. Triazolam administered at 0.1, 0.2, or 0.3 mg/kg markedly impaired performance as assessed by either swim time or errors. There were no differences in performance of rats previously treated with triazolam, diazepam, or vehicle in learning another new maze after drug treatment was terminated. These data demonstrate that both diazepam and triazolam affect acquisition but not recall of maze configurations and support similar conclusions reached using other types of tasks in humans and animals.
机译：经常服用的苯二氮卓类药物地西epa（Valium）和三唑仑（Halcion）的不良反应之一是人类顺行性记忆障碍。本文描述的实验比较了三唑仑和地西epa对水迷宫任务的性能影响，水迷宫任务对影响学习和记忆的药物敏感。所使用的水迷宫是一种具有小巷和门选择的传统迷宫，与莫里斯开放水迷宫不同。查找水上平台所需的时间和游泳期间犯下的错误被用作性能指标。在先前学习的迷宫配置和新迷宫配置的获取上对大鼠进行了测试。在之前学习过的迷宫进行测试之前30分钟，既不注射地西epa（0.25、1.0或2.0 mg / kg）也未注射三唑仑（0.05、0.2或0.3 mg / kg）影响游泳时间或犯错。在每天对三种不同的新迷宫配置进行训练之前，给予地西epa（0.5、1.0或2.0 mg / kg，IP）不会影响游泳时间，但会增加游泳错误。通过游泳时间或错误来评估，以0.1、0.2或0.3 mg / kg的三唑仑施用显着损害了运动能力。在终止药物治疗后，先前用三唑仑，地西epa或媒介物治疗的大鼠学习另一种新迷宫的性能没有差异。这些数据表明，地西epa和三唑仑均会影响采集，但不会影响迷宫的构型，并支持在人类和动物中使用其他类型的任务得出的类似结论。

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