• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Prenatal buprenorphine exposure and sexually dimorphic nonreproductive behaviors in rats.
【24h】

Prenatal buprenorphine exposure and sexually dimorphic nonreproductive behaviors in rats.

机译：产前丁丙诺啡暴露和大鼠性二形性非生殖行为。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This set of experiments examined the effects of prenatal buprenorphine (BUP) exposure on three measures of sexual differentiation in rats. Pregnant female rats were divided into four treatment groups: 0.6 mg/kg BUP, 0.3 mg/kg BUP, a pair-fed control (PFC), and an untreated control (UTC). Drugs were injected starting on gestation day (GD) 6 and continuing through GD 20 with a 48-h interval between drug administrations. Three variables were examined in the offspring: anogenital (AG) distance on postnatal day (PND) 1, spontaneous parental behavior on PNDs 23-28, and saccharin consumption on PNDs 42-55. Whereas prenatal BUP exposure had no effect on AG distance, spontaneous parental behavior was impaired in the 0.6-mg/kg-exposed offspring on two measures: pup-retrieval latencies and pup-directed behaviors. Furthermore, although both control groups and the 0.3-mg/kg-exposed offspring showed the expected sex difference in consumption of a 0.25% saccharin solution, this difference was not displayed by the 0.6-mg/kg-exposed offspring. These findings suggest that exposure to relatively high doses of buprenorphine during development may have long-term effects on behavior.
机译：这组实验检查了产前丁丙诺啡（BUP）暴露对大鼠性分化的三种测量的影响。将怀孕的雌性大鼠分为四个治疗组：0.6 mg / kg BUP，0.3 mg / kg BUP，配对喂养对照（PFC）和未经治疗的对照（UTC）。药物从妊娠第6天（GD）开始注射，一直持续到GD 20，每次给药间隔48小时。在后代中检查了三个变量：产后一天（PND）的生殖器（AG）距离，PND 23-28的自发父母行为和PND 42-55的糖精消耗。产前BUP暴露对AG距离没有影响，但暴露于0.6 mg / kg的后代的自发父母行为受到以下两个因素的影响：p取回潜伏期和p指导行为。此外，尽管对照组和暴露于0.3mg / kg的后代在食用0.25％糖精溶液中均显示出预期的性别差异，但暴露于0.6mg / kg的后代并未显示出这种差异。这些发现表明，在发育过程中接触相对较高剂量的丁丙诺啡可能会对行为产生长期影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号