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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >State-dependency of conditioning and extinction of an appetitive response with amphetamine and midazolam.
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State-dependency of conditioning and extinction of an appetitive response with amphetamine and midazolam.

机译：状态依赖性和安非他命和咪达唑仑消灭食欲不振。

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Rats received a single conditioning session in which unsignaled food pellets were delivered to the food magazine of a training box, followed by a single extinction session without pellet presentations. Groups of rats differed in the drug state induced prior to conditioning and extinction according to a 2 x 2 design using d-amphetamine sulphate (AMP, 0.5 mg/kg, S.C.) and midazolam (MID, 0.1 mg/kg, S.C.). Subsequently, all rats received nonreinforced test sessions under AMP and MID. The dependent measure was the frequency of magazine visits during selected portions of each session. Rats that received extinction in the same drug state as had been present during conditioning did not respond significantly more during the extinction session than rats extinguished in a different drug state. This implies that conditioning was not state dependent. However, during the AMP tests, the rats extinguished under MID responded more under AMP than under MID, whereas the rats extinguished under AMP did not respond differentially during the tests under AMP vs. MID. These results were interpreted as reflecting the joint operation of state-dependent extinction and unconditioned drug effects. As in studies manipulating external contextual stimuli, extinction proved to be more vulnerable to becoming context dependent than conditioning.
机译：大鼠接受单次调理，其中将无信号的食物颗粒递送到训练箱的食物盒中，然后进行一次不显示颗粒的灭绝过程。根据2 x 2设计，使用硫酸D-苯异丙胺（AMP，0.5 mg / kg，S.C.）和咪达唑仑（MID，0.1 mg / kg，S.C.）根据2 x 2设计，各组大鼠在适应和灭绝之前诱导的药物状态有所不同。随后，所有大鼠均接受AMP和MID的非强化测试。取决于指标的是在每个会话的选定部分中杂志访问的频率。与在不同药物状态下灭绝的大鼠相比，在适应过程中处于相同药物状态下灭绝的大鼠在灭绝过程中的反应没有明显更多。这意味着条件不取决于状态。但是，在AMP试验中，在AMP下灭绝的大鼠对AMP的反应比在MID下灭绝，而在AMP与MID进行试验时，在AMP下灭绝的大鼠没有差异。这些结果被解释为反映了状态依赖性灭绝和无条件药物作用的联合作用。正如在操纵外部情境刺激的研究中一样，灭绝被证明比情境更容易变得依赖于情境。

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