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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Dosage choices of rats for morphine, for heroin, and between morphine and heroin.
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Dosage choices of rats for morphine, for heroin, and between morphine and heroin.

机译：大鼠吗啡，海洛因以及吗啡和海洛因之间的剂量选择。

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摘要

Each of four doses of intravenous morphine and four of intravenous heroin was tested for reinforcing efficacy, and comparisons were made among the four morphine doses, among the four heroin doses, and between morphine and heroin. Rats with venous catheters performed one daily forced run for 75 s to one of the two compartments of a spatial choice apparatus, with compartments and doses or drugs alternating over days. In each trial, the accessible compartment depended on which dose (including zero dose) or drug a rat was to receive. After 18-28 forced trials and 0 or 4 reinforced choice trials, efficacies of the different doses and drugs were measured by subsequent compartment choices. Increasing dose effects on choice were found for morphine (0.32, 1.0, 3.2, and 10.0 mg/kg intravenously) and for heroin (0.032, 0.10, 0.32, and 1.0 mg/kg intravenously). A 32:1 morphine:heroin dose ratio produced nearly equal choice. Dose effects were more evident in within-subjects experiments (each rat received two doses or two drugs) than in between-subjects experiments (each rat received one dose of one drug.
机译：对四剂静脉内吗啡和四剂海洛因的增强作用进行了测试，并比较了四剂吗啡，四剂海洛因之间以及吗啡和海洛因之间的作用。装有静脉导管的大鼠每天在空间选择装置的两个隔室之一中进行一次每天75秒的强制运行，隔室和剂量或药物在几天内交替进行。在每个试验中，可进入的隔室取决于大鼠要接受的剂量（包括零剂量）或药物。在进行18-28次强制试验和0或4次强化选择试验后，通过随后的隔室选择来测量不同剂量和药物的疗效。对于吗啡（静脉注射0.32、1.0、3.2和10.0 mg / kg）和海洛因（静脉注射0.032、0.10、0.32和1.0 mg / kg），发现剂量选择的影响增加。 32：1的吗啡：海洛因剂量比产生了几乎相等的选择。与受试者之间的实验（每只大鼠接受一种剂量的一种药物）相比，受试者内部的实验（每只大鼠接受两种剂量或两种药物）的剂量效应更为明显。

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