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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >D1 and D2 dopamine and opiate receptors are involved in the restraint stress-induced sensitization to the psychostimulant effects of amphetamine.
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D1 and D2 dopamine and opiate receptors are involved in the restraint stress-induced sensitization to the psychostimulant effects of amphetamine.

机译：D1和D2多巴胺和鸦片受体与抑制应激诱导的对苯丙胺的精神刺激作用的致敏有关。

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摘要

The time course of the restraint stress-induced sensitization to the stimulant effects of amphetamine (AMPH, 0.5 mg/kg IP) on locomotor activity was investigated for up to 8 days. In a series of separate experiments, the involvement of opioid and dopaminergic mechanisms in the development of acute restraint stress-induced behavioral sensitization were characterized. Both a single restraint session (2 h) and chronic restraint (2 h per day for 7 days) similarly potentiated the effects of AMPH on motor activity. This behavioral sensitization was prevented by the administration of naltrexone (2 mg/kg IP), haloperidol (1 mg/kg IP), sulpiride (60 mg/kg IP) or SCH23390 (0.5 mg/kg IP) 10-20 min prior to restraint. These results indicate that 1) the development of sensitization to amphetamine-induced effects on motor activity does not depend on the length of exposure to stress (acute or chronic). 2) the stimulation of both D1 and D2 dopaminergic receptors is necessary for the development of the restraint stress-induced sensitization to AMPH and 3) and opioid system is also implicated in this sensitization process.
机译：研究了抑制应激诱导的对苯丙胺（AMPH，0.5 mg / kg IP）对运动活动的刺激作用的敏化作用的时间过程，长达8天。在一系列单独的实验中，对阿片样物质和多巴胺能机制在急性束缚应激诱导的行为敏化发展中的作用进行了表征。一次约束（2小时）和慢性约束（每天2小时，共7天）都相似地增强了AMPH对运动活动的影响。在行为发生前10-20分钟服用纳曲酮（2 mg / kg IP），氟哌啶醇（1 mg / kg IP），舒必利（60 mg / kg IP）或SCH23390（0.5 mg / kg IP）可预防这种行为过敏克制。这些结果表明：1）对苯丙胺诱导的运动活动影响的敏化程度的提高并不取决于暴露于压力（急性或慢性）的时间。 2）D1和D2多巴胺能受体的刺激对于限制应激诱导的对AMPH的敏化的发展是必要的，并且3）阿片样物质系统也与该敏化过程有关。

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