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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Acute and subchronic effects of tiapride on isolation-induced aggression in male mice.
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Acute and subchronic effects of tiapride on isolation-induced aggression in male mice.

机译：替加必利对雄性小鼠隔离诱发的侵略的急性和亚慢性影响。

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Although the antiaggressive properties of several atypical neuroleptics are known, the actions of tiapride (a selective dopaminergic D2-receptor antagonist) on agonistic behavior have not been explored and there are no studies comparing acute and subchronic effects of this compound on aggression in rodents. In this work, the effects of tiapride (20-100 mg/kg, IP), administered acutely or subchronically for 10 days, on agonistic behaviour elicited by isolation in male mice were examined. Individually housed mice were exposed to anosmic "standard opponents" 30 min after drug administration, and the encounters were videotaped and evaluated using an ethologically based analysis. Tiapride decreased time spent in offenssive behaviors significantly, without an impairment of motor activity (60 and 80 mg/kg). Moreover, no tolerance to tiapride antiaggressive activity was observed after repeated administration of the drug. On the contrary, the action on immobility showed a clear tolerance development with repeated injections (100 mg/kg). The divergence found in the temporal course of tolerance to tiapride in its antiaggressive and motor effects is discussed.
机译：尽管已知几种非典型抗精神病药的抗攻击特性，但尚未探讨噻帕必利（一种选择性的多巴胺能D2受体拮抗剂）对激动剂的作用，也没有研究比较该化合物对啮齿动物侵害的急性和亚慢性作用。在这项工作中，研究了急性或亚慢性给予10天的tiapride（20-100 mg / kg，IP）对雄性小鼠隔离引起的激动行为的影响。在给药后30分钟，将单独饲养的小鼠暴露于厌食性的“标准对手”中，并对相遇进行录像，并使用基于行为学的分析进行评估。 Tiapride可以显着减少花在进攻行为上的时间，而不会损害运动活性（60和80 mg / kg）。此外，在重复给药后未观察到对tiapride抗侵袭活性的耐受性。相反，对固定性的作用显示出反复注射（100 mg / kg）的明显耐受性。讨论了在对tiapride的抗攻击和运动效应耐受性的时间过程中的差异。

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