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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Transient emotional changes elicited by intraperitoneal saline injection: effect of naloxone and flumazenil.
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Transient emotional changes elicited by intraperitoneal saline injection: effect of naloxone and flumazenil.

机译：腹膜内注射盐水引起的短暂情绪变化：纳洛酮和氟马西尼的作用。

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摘要

The effect of the intraperitoneal (i.p.) saline injection was assessed by using the defensive burying (DB) and the elevated plus-maze (EPM) anxiety paradigms in rats. Animals were handled gently by the body, injected i.p. with saline solution, 2 ml/kg, and tested independently in the defensive burying as well as in the elevated plus-maze test at different times after the i.p. injection: 1.5, 3, 5, 10, 15, and 30 min. A transient effect of i.p. saline injection was observed (i.e., increased DB in animals tested 1.5 min after injection) and a decrease in this parameter when studied 3 min after the injection. No changes at 5, 10, 15, and 30 min after the injection were found. To discriminate the putative participation of the opiate peptide and benzodiazepine receptors in the actions of the i.p. injection, flumazenil (5 mg/kg) and nalozone (1 mg/kg) were administered. The increase in DB at 1.5 min was masked by double injection, an effect blocked by naloxone, but not by flumazenil, while both of them reverted the decrease in DB response in animals tested 3 min after injection. A partial action of the i.p. in the animals tested in the elevated plus-maze test was found. Present results are discussed on the basis of behavioral and pharmacological evidence.
机译：通过使用大鼠的防御性掩埋（DB）和升高的迷宫（EPM）焦虑范例评估腹膜内（i.p.）盐水注射的效果。腹腔注射动物轻柔地处理动物。用2 ml / kg的盐溶液，分别在腹腔注射后的不同时间在防御性掩埋以及高架迷宫测试中进行独立测试。注射：1.5、3、5、10、15和30分钟。 i.p.的短暂影响观察到了盐水注射（即在注射后1.5分钟测试的动物中DB的增加），而在注射后3分钟进行研究时，该参数的降低。注射后第5、10、15和30分钟未发现变化。区分阿片肽和苯并二氮杂receptor受体的假定参与i.p.注射氟马西尼（5 mg / kg）和那洛宗（1 mg / kg）。 1.5分钟时DB的增加被双重注射所掩盖，纳洛酮阻止了这一作用，但氟马西尼则没有，但两者都恢复了注射3分钟后测试动物的DB反应的下降。 i.p.的部分动作在高架迷宫试验中测试的动物中发现。目前的结果在行为和药理学证据的基础上进行了讨论。

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