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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effects of concurrent administration of +/-3,4-methylenedioxymethamphetamine and cocaine on conditioned place preference in the adult male rat.
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The effects of concurrent administration of +/-3,4-methylenedioxymethamphetamine and cocaine on conditioned place preference in the adult male rat.

机译：成年雄性大鼠同时给予+/- 3,4-亚甲二氧基甲基苯丙胺和可卡因对条件性位置偏爱的影响。

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摘要

Conditioned place preference (CPP), a commonly used model for studying the role of contextual cues in drug reward and drug seeking, was employed to explore possible behavioral interactions between (+/-)3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") and cocaine. On each of four occasions, adult male rats received one of three doses of MDMA (0 mg/kg, 5 mg/kg, 10 mg/kg; administered subcutaneously [s.c.]) combined with one of three doses of cocaine (0 mg/kg, 2.5 mg/kg, 5 mg/kg; administered intraperitoneally [i.p.]), and were then tested in a CPP paradigm. The results showed MDMA-induced CPP at a unit dose of 5 mg/kg, but at the 10 mg/kg dose there was a return to baseline (control) performance levels. For cocaine alone, CPP increased in a linear fashion as the drug dose was increased. Concurrent administration resulted in antagonism of each drug, but there was evidence that this pattern was reversible at higher doses of the respective drugs. These data are instructive insofar as they suggest that the behavioral and neurochemical effects of MDMA and cocaine presented in isolation are dramatically altered when the two drugs are presented in combination.
机译：条件性位置偏好（CPP）是研究上下文线索在药物奖励和寻找药物中作用的常用模型，用于研究（+/-）3,4-亚甲基二氧基甲基苯丙胺（MDMA;“摇头丸”）之间可能的行为相互作用和可卡因。在四种情况下，成年雄性大鼠分别接受三种剂量的MDMA（0 mg / kg，5 mg / kg，10 mg / kg;皮下注射[sc]）之一与三种剂量的可卡因（0 mg / kg kg，2.5 mg / kg，5 mg / kg;腹膜内给药[ip]），然后在CPP范式中进行测试。结果显示，MDMA诱导的CPP的单位剂量为5 mg / kg，但在10 mg / kg的剂量下，恢复到基线（对照）性能水平。对于单独的可卡因，随着药物剂量的增加，CPP呈线性增加。同时给药导致每种药物的拮抗作用，但是有证据表明，在更高剂量的相应药物下，这种模式是可逆的。这些数据具有指导意义，因为它们提示当两种药物组合使用时，单独存在的MDMA和可卡因的行为和神经化学作用会发生巨大变化。

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