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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >FOS expression induced by an ethanol-paired conditioned stimulus.
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FOS expression induced by an ethanol-paired conditioned stimulus.

机译：FOS表达由乙醇配对的条件刺激诱导。

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摘要

To identify brain areas involved in ethanol-induced Pavlovian conditioning, brains of male DBA/2J mice were immunohistochemically analyzed for FOS expression after exposure to a conditioned stimulus (CS) previously paired with ethanol (2 g/kg) in two experiments. Mice were trained with a procedure that normally produces place preference (Before: ethanol before the CS) or one that normally produces place aversion (After: ethanol after the CS). Control groups received unpaired ethanol injections in the home cage (Delay) or saline only (Naive). On the test day, mice were exposed to the 5-min CS 90 min before sacrifice. Before groups showed a conditioned increase in activity, whereas the After group showed a conditioned decrease in activity. FOS expression after a drug-free CS exposure was significantly higher in Before-group mice than in control mice in the bed nucleus of the stria terminalis (Experiment 1) and anterior ventral tegmental area (Experiments 1-2). Conditioned FOS responses were also seen in areas of the extended amygdala and hippocampus (Experiment 2). However, no conditioned FOS changes were seen in any brain area examined in After-group mice. Overall, these data suggest an important role for the mesolimbic dopamine pathway, extended amygdala and hippocampus in ethanol-induced conditioning.
机译：为了确定涉及乙醇诱导的巴甫洛夫条件的大脑区域，在两个实验中，先暴露于条件刺激（CS）与乙醇（2 g / kg）配对后，对雄性DBA / 2J小鼠的大脑进行免疫组织化学分析，分析其FOS表达。使用通常会产生位置偏爱的程序（之前：CS前的乙醇）或通常会产生位置厌恶的程序（之后：CS之后的乙醇）训练小鼠。对照组在家庭笼中接受不成对的乙醇注射（延迟）或仅接受生理盐水（幼稚）。在测试当天，小鼠处死前90分钟暴露于5分钟的CS中。前组显示出有条件的活动增加，而后组显示出有条件的活动减少。在前组小鼠中，无药CS暴露后FOS的表达显着高于对照组，其在纹状体末端床核（实验1）和前腹侧被盖区（实验1-2）中。在延伸的杏仁核和海马区域也观察到条件性FOS反应（实验2）。但是，在After-group小鼠中检查的任何大脑区域均未观察到条件FOS的变化。总体而言，这些数据表明在乙醇诱导的调节中，中脑边缘多巴胺途径，杏仁核和海马体的扩展发挥重要作用。

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