• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Milnacipran attenuates hyperalgesia and potentiates antihyperalgesic effect of tramadol in rats with mononeuropathic pain.
【24h】

Milnacipran attenuates hyperalgesia and potentiates antihyperalgesic effect of tramadol in rats with mononeuropathic pain.

机译：Milnacipran可减轻单神经性疼痛大鼠的痛觉过敏并增强曲马多的抗痛觉过敏作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Milnacipran is a non-tricyclic antidepressant drug which selectively inhibits serotonin and noradrenaline re-uptake and is recommended in the treatment of various chronic pain syndromes. Many studies have shown that compounds known to block monoamine uptake potentiate the antinociceptive effects of opioids. This study investigates the effect of milnacipran alone or in combination with an opiodergic drug, i.e. tramadol, on hyperalgesia in a rat model of neuropathic pain. The contribution of serotonergic, noradrenergic and opioidergic systems in the potential antihyperalgesic effect of milnacipran has also been examined. Chronic constriction injury was induced in rats by loose ligation of the sciatic nerve and neuropathic pain was evaluated 14 days after surgery. Intraperitoneal acute injection of milnacipran 60 mg/kg produced an antihyperalgesic effect which was prevented by pretreating systemically with alpha-methyl-p-tyrosine, an inhibitor of noradrenaline synthesis; parachlorophenylalanine, an inhibitor of serotonin synthesis; and naloxone, an antagonist of opioidergic receptors. Co-administration of milnacipran 40 mg/kg with tramadol (20 and 40 mg/kg) potentiated the antihyperalgesic effect of tramadol. Milnacipran has an antihyperalgesic effect mediated by serotonergic, noradrenergic and opioidergic systems and the combined use of tramadol with milnacipran potentiates the effect of tramadol in the management of neuropathic pain.
机译：米那普仑是一种非三环类抗抑郁药，可选择性抑制5-羟色胺和去甲肾上腺素的再摄取，建议用于治疗各种慢性疼痛综合症。许多研究表明，已知可阻止单胺摄取的化合物可增强阿片类药物的抗伤害感受作用。这项研究调查了在神经性疼痛大鼠模型中，米那普仑单独使用或与阿片类药物（曲马多）合用对痛觉过敏的作用。还研究了血清素能，去甲肾上腺素能和阿片维甲酸能系统对米那普仑潜在的抗痛觉过敏作用的作用。坐骨神经松散结扎可诱发大鼠慢性收缩损伤，并在术后14天评估神经性疼痛。腹膜内急性注射米那普仑60 mg / kg产生抗痛觉过敏作用，可通过用去甲肾上腺素合成抑制剂α-甲基-p-酪氨酸全身预处理来预防。对氯苯丙氨酸，5-羟色胺合成抑制剂;和纳洛酮，阿片受体拮抗剂。米那普仑40 mg / kg与曲马多（20和40 mg / kg）共同给药可增强曲马多的抗痛觉过敏作用。米那普仑具有由血清素能，去甲肾上腺素能和阿片皮酸能系统介导的抗痛觉过敏作用，曲马多与米那普仑的组合使用可增强曲马多在神经性疼痛管理中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号