• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Influence of age at drinking onset on the alcohol deprivation effect and stress-induced drinking in female rats.
【24h】

Influence of age at drinking onset on the alcohol deprivation effect and stress-induced drinking in female rats.

机译：饮酒年龄对雌性大鼠酒精剥夺作用和应激诱导饮酒的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have recently observed increased stress responsiveness with regard to alcohol consumption in male rats that consumed alcohol since their adolescent period. Thus, early age at drinking onset can induce enhanced stress-induced alcohol drinking in male rats. However, it is not known whether female rats respond in a similar way. Therefore, we compared the drinking behavior of two female Wistar rat groups--one that acquired alcohol consumption during adolescence (adolescent group) and the other that acquired their drinking during adulthood (adult group) in a model of long-term voluntary alcohol drinking with repeated deprivation and stress phases. Furthermore, we studied the influence of age at drinking onset on the efficacy of acamprosate treatment. Thirty-nine female Wistar rats aged 31 days (adolescents) and 71 days (adults) were given ad libitum access to water, as well as to 5% and 20% ethanol solutions during an observation period of 29 weeks. A deprivation phase of 14 days was introduced following8 weeks of access to alcohol in order to measure the alcohol deprivation effect (ADE). After 15 and 25 weeks of alcohol access, all animals were subjected for 3 consecutive days of forced swim and electric foot-shock stress, respectively. After 29 weeks of access to alcohol all animals underwent a second deprivation phase and the subsequent ADE was measured either under acamprosate (200 mg/kg) or vehicle treatment. Drinking before the first deprivation phase was not different between animal groups. However, the expression of the first ADE was more pronounced in adult female rats and alcohol intake stayed increased for the remainder of the experiment in the adult group. Both repeated swim stress and foot-shock stress produced a more pronounced increase in ethanol consumption in the adolescent group compared to the adult group. Acamprosate reduced relapse-like drinking in the adult female rat group. However, it had no effect on the ADE in the adolescent group. In conclusion, female rats that initiate alcohol consumption during adolescence might be more susceptible to stress-induced alcohol consumption. Adolescent alcohol drinking might also result in a reduced response to acamprosate.
机译：我们最近观察到自青春期以来开始饮酒的雄性大鼠对饮酒的压力反应性增强。因此，饮酒开始的早期年龄可以诱导雄性大鼠应激性饮酒的增强。但是，尚不知道雌性大鼠是否以类似的方式反应。因此，我们在长期自愿饮酒的模型中比较了两个雌性Wistar大鼠组的饮酒行为-一个在青春期获得饮酒（青少年组），另一个在成年期获得饮酒（成人组）。反复的剥夺和压力阶段。此外，我们研究了饮酒年龄对阿坎酸治疗效果的影响。在29周的观察期内，对39只31天（青少年）和71天（成人）的Wistar雌性大鼠自由饮水，以及5％和20％的乙醇溶液。在接触酒精8周后，开始了14天的剥夺阶段，以衡量酒精剥夺效果（ADE）。饮酒15周和25周后，分别对所有动物进行连续3天的强迫游泳和电击脚压力。在接触酒精29周后，所有动物都进入了第二次剥夺阶段，随后在阿坎酸（200 mg / kg）或赋形剂处理下测量了随后的ADE。动物之间在第一个剥夺阶段之前的饮酒没有差异。但是，在成年雌性大鼠的其余实验中，第一个ADE的表达在成年雌性大鼠中更为明显，并且酒精摄入保持增加。与成年组相比，青少年组反复的游泳压力和足部冲击都使乙醇的消耗量增加更为明显。阿坎酸减少成年雌性大鼠组中的复发样饮酒。但是，它对青少年组的ADE没有影响。总之，在青春期开始饮酒的雌性大鼠可能更容易因压力导致饮酒。青少年饮酒也可能导致对阿坎酸的反应减少。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号