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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Ethanol sensitization in a neurodevelopmental lesion model of schizophrenia in rats.
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Ethanol sensitization in a neurodevelopmental lesion model of schizophrenia in rats.

机译：在精神分裂症大鼠神经发育病变模型中的乙醇增敏。

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Substance use disorder comorbidity in schizophrenia may reflect dysfunctional cortical-striatal-limbic circuitry commonly involved in the addiction process and the pathogenesis of schizophrenia. Rats with neonatal ventral hippocampal lesions (NVHL) demonstrate post-adolescent onset of schizophrenia-like symptoms and increased addiction vulnerability in paradigms using cocaine in adulthood. Here, we investigated response profiles of young adult NVHL vs. SHAM rats to ethanol, an addictive drug with many psychopharmacological effects divergent from those of cocaine, in a locomotor sensitization paradigm. Over 15 days of daily injections of saline, low (0.15 g/kg) or high (1.0 g/kg) doses of ethanol, NVHL rats showed stimulatory effects at the low dose compared to saline and high-dose conditions, while SHAM rats showed expected patterns of dose-dependent suppression of locomotor activity. In a challenge session 2 weeks later in which a moderate dose (0.25 g/kg) of ethanol was given to all subjects, NVHL rats with history of prior ethanol exposure showed greater locomotor activity consistent with installment of alcohol-induced sensitization not present in SHAMs. These findings provide further evidence of enhanced short- and long-term responsivity to abused drugs in a neurodevelopmental model of schizophrenia, and may reflect potentiation of common mechanisms of addiction shared between pharmacologically diverse addictive drugs.
机译：精神分裂症的物质使用障碍合并症可能反映了功能障碍的皮质-纹状体-边缘回路，通常与精神分裂症的成瘾过程和发病机理有关。患有新生腹侧海马病变（NVHL）的大鼠在成年后使用可卡因表现出精神分裂症样症状的青春期发作和成瘾易感性增加。在这里，我们在运动敏化范例中研究了成年NVHL与SHAM大鼠对乙醇的反应曲线，乙醇是一种成瘾性药物，具有许多与可卡因不同的心理药理作用。在每天注射生理盐水，低剂量（0.15 g / kg）或高剂量（1.0 g / kg）的乙醇的15天中，与生理盐水和高剂量条件相比，NVHL大鼠在低剂量时显示出刺激作用。预期的剂量依赖性运动活动抑制模式。在2周后的挑战赛中，向所有受试者服用中等剂量（0.25 g / kg）的乙醇，有先前乙醇暴露史的NVHL大鼠表现出更大的运动能力，与SHAMs中不存在的酒精诱导的致敏作用相一致。 。这些发现为精神分裂症的神经发育模型中滥用药物的短期和长期反应性增强提供了进一步的证据，并且可能反映了药理学上不同的成瘾药物之间共同的成瘾机制的增强。

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