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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Association between illicit drug and alcohol use and first manic episode.
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Association between illicit drug and alcohol use and first manic episode.

机译：非法药物和酒精使用与首次躁狂发作之间的关联。

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摘要

In light of the established influence of substance use on the onset, course, and outcome of bipolar disorder, we performed a retrospective chart review of patients with bipolar I disorder participating in a randomized controlled trial to further investigate the relationship between alcohol and substance use and first onset of mania. A total of 59.4% (N=101) of the 170 participants were determined to have a history of substance and/or alcohol use. Among the 101 participants with SU, use was coded in 10 (9.9%) as immediately preceding, in 50 (49.5%) as preceding mania, in 7 (6.9%) as following mania, and in 34 (33.7%) as indeterminable. Of the 10 participants with immediately preceding use, 5 experienced their first manic episode immediately after discontinuing a substance. Our findings support earlier reports detailing the high prevalence of substance use among patients with bipolar disorder. Treatments targeting alcohol and substance use among individuals with bipolar disorder are clearly needed, as are prophylactic treatments targeting adolescents and young adults who are at risk for either bipolar disorder or alcohol and substance related disorders.
机译：鉴于药物滥用对双相情感障碍的发作，病程和结局的既定影响，我们对参加随机对照试验的双相I情感障碍患者进行了回顾性图表审查，以进一步调查酒精与药物滥用之间的关系。躁狂症的首次发作。 170名参与者中，共有59.4％（N = 101）被确定具有物质和/或酒精使用史。在101名患有SU的参与者中，使用前的躁狂程度分别为10（9.9％），前躁狂症的50（49.5％），后躁狂症的7（6.9％）和不确定的34（33.7％）。在10名之前立即使用过的参与者中，有5名在停止使用某种物质后立即经历了第一次躁狂发作。我们的研究结果支持较早的报道，详细报道了躁郁症患者中药物滥用的普遍性。显然需要针对双相情感障碍患者中的​​酒精和物质使用的治疗，以及针对有双相情感障碍或与酒精和物质相关的疾病风险的青少年的预防性治疗。

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