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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Impairment of acquisition of cocaine self-administration in rats maintained on a high-fat diet.
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Impairment of acquisition of cocaine self-administration in rats maintained on a high-fat diet.

机译：维持高脂饮食的大鼠可卡因自我给药的获得障碍。

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摘要

Variations in dietary constituents such as carbohydrate are known to alter psychostimulant function in brain. Relatively few studies have examined the reinforcing effects of psychostimulants in subjects maintained on high-fat diets. The present experiment compared the rate of acquisition of an operant response for intravenous (i.v.) cocaine infusions (0.2 mg/kg) in rats fed either a chow-pellet diet or a 35.9% (by weight) high-fat diet for 45 days prior to cocaine self-administration testing. Rats maintained on a high-fat diet for 45 days exhibited diminished acquisition of cocaine self-administration, and this effect was not a function of dietary-induced obesity. The results suggest that prolonged exposure to a high-fat diet diminishes the efficacy of cocaine reinforcement.
机译：饮食成分（例如碳水化合物）的变化已知会改变大脑中的心理刺激功能。相对较少的研究检查了精神兴奋剂对高脂饮食维持的受试者的增强作用。本实验比较了在45天之前喂以粗粒饲料或35.9％（按重量计）高脂饮食的大鼠静脉（iv）可卡因输注（0.2 mg / kg）的手术反应获得率。进行可卡因自我管理测试。维持高脂饮食45天的大鼠表现出可卡因自我给药的获得减少，并且这种作用不是饮食诱发的肥胖的作用。结果表明，长期接触高脂饮食会降低可卡因强化的功效。

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