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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Microdialysis and the neurochemistry of addiction.
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Microdialysis and the neurochemistry of addiction.

机译：微透析和成瘾的神经化学。

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摘要

Drug addiction is a process beginning with the initial exposure to a drug of abuse, and leading, in some individuals, to chronic habitual use, and high rates of relapse. Microdialysis allows researchers to monitor the neurochemical changes that occur in the brain after the initial exposure to a drug, and the neurochemical changes that occur with repeated exposure. These changes in the brain are often referred to as drug-induced neuroplasticity, and the aim of this article is to review studies that have utilized microdialysis to increase our understanding of the neuroplasticity that occurs in the process of addiction. We will review how several neurotransmitter systems, including glutamate, GABA, the monoamines, and others, are altered after chronic drug exposure, and how microdialysis can be used to determine if putative treatments for addiction can reverse the drug-induced neuroplasticity in these systems. We will also briefly discuss our recent research using a known change in GABA neurotransmission that occurs during reinstatement of drug-seeking to screen for possible novel treatments to prevent relapse. Overall, microdialysis in combination with other behavioral and pharmacological techniques has greatly increased our understanding of addiction-related neuroplasticity, and provides a means for discovering new ways to prevent these changes and treat addiction.
机译：吸毒成瘾是一个过程，从最初接触滥用药物开始，并导致某些人长期习惯使用和高复发率。微透析使研究人员可以监测初次接触药物后大脑中发生的神经化学变化，以及反复接触后发生的神经化学变化。大脑中的这些变化通常被称为药物诱导的神经可塑性，本文的目的是回顾利用微透析提高对成瘾过程中发生的神经可塑性的理解的研究。我们将回顾慢性药物暴露后如何改变包括谷氨酸，GABA，单胺等在内的几种神经递质系统，以及如何利用微透析来确定推定的成瘾疗法是否可以逆转这些系统中药物诱导的神经可塑性。我们还将简要讨论我们最近的研究，该研究使用已知的GABA神经传递变化，该变化发生在恢复寻药过程中，以筛选可能的预防复发的新疗法。总体而言，微透析与其他行为和药理技术相结合，大大增加了我们对成瘾相关的神经可塑性的理解，并为发现预防这些变化和治疗成瘾的新方法提供了一种手段。

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