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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Sexual incentive motivation in old male rats: The effects of sildenafil and a compound (Impaza) stimulating endothelial NO synthase.
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Sexual incentive motivation in old male rats: The effects of sildenafil and a compound (Impaza) stimulating endothelial NO synthase.

机译：老年雄性大鼠的性刺激动机：西地那非和一种化合物（Impaza）刺激内皮一氧化氮合酶的作用。

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摘要

Several proerectile drugs act on the nitric oxide-cyclic guanosine monophopsphate pathway, which is known to influence rat copulatory behavior. In the present study we evaluated the effects of two proerectile compounds, one (Impaza) acting on endothelial nitric oxide synthase, and the other (sildenafil) on phosphodiesterase 5, on sexual incentive motivation in male rats displaying a spontaneously low level of motivation and copulatory behavior. About 20 months old male Fisher 344 rats were tested in a procedure for evaluating the intensity of sexual incentive motivation and in standard mating tests. For comparison, a group of young (about 4 months) Fisher 344 males was tested in parallel. This group did not receive any drug treatment. Impaza was administered in two doses, daily for 28 days, and sildenafil was given at a dose of 3 mg/kg twice a week during 28 days. Tests for sexual incentive motivation and copulatory behavior were performed immediately before the beginning of drug treatments, and on days 7, 14 and 28 of treatment. All treatment groups displayed a very low level of copulatory behavior and a sexually receptive female was not a more powerful incentive than another male at the tests performed before and on days 7 and 14 of treatment. On day 28 of treatment, the group treated with Impaza, 3 ml, displayed a preference for the sexually receptive female, while no such preference was found in the other groups. Furthermore, the preference score was above that of controls in this group. Both Impaza, 3 ml, and sildenafil reduced approach to the male in the test for sexual incentive motivation, suggesting that social motivation was reduced. These data suggest that compounds affecting the nitric oxide-cyclic guanosine monophopsphate pathway may modify both sexual and social motivation in old rats.
机译：几种保护性药物作用于一氧化氮-环鸟嘌呤单磷酸途径，已知会影响大鼠的交配行为。在本研究中，我们评估了两种保护性化合物，一种作用于内皮一氧化氮合酶（Impaza），另一种作用于磷酸二酯酶5（sildenafil）对雄性大鼠性刺激的影响，自发性和交配性水平较低行为。在评估性动机动机强度的程序中以及在标准的交配测试中测试了约20个月大的雄性Fisher 344大鼠。为了进行比较，平行测试了一组年轻的（约4个月）Fisher 344雄性。该组未接受任何药物治疗。每天两次服用Impaza，共28天，在28天内每周两次以3 mg / kg的剂量给予西地那非。在开始药物治疗之前以及治疗的第7、14和28天进行了性动机和交往行为测试。在治疗的第7天和第14天以及在治疗的第7天，所有治疗组的交往行为水平都非常低，并且女性接受性行为的动机并不比其他男性强。在治疗的第28天，接受3毫升Impaza治疗的组表现出对性接受女性的偏爱，而在其他组中则没有发现这种偏爱。此外，该组的偏好得分高于对照组。在性动机测试中，Impaza，3 ml和西地那非均降低了对男性的接近度，表明社交动机降低了。这些数据表明，影响一氧化氮-环鸟嘌呤单磷酸途径的化合物可能会改变老年大鼠的性和社会动机。

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