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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Concurrent access to sucrose pellets decreases methamphetamine-seeking behavior in Lewis rats.
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Concurrent access to sucrose pellets decreases methamphetamine-seeking behavior in Lewis rats.

机译：并用蔗糖颗粒可减少Lewis大鼠的去氧麻黄碱行为。

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Investigation of the role of choice between use of drugs of abuse and pursuit of alternative non-drug reinforcers is receiving greater attention. An understanding of the determinants influencing choice between drugs and alternative reinforcers will eventually lead to an understanding to the neural substrates of the drug altered brain. We investigated the impact of concurrent access to sucrose pellets on methamphetamine self-administration and self-regulated reinstatement of methamphetamine seeking following extinction training in Lewis rats. Our results from the self-administration experiment show that rats with concurrent access to sucrose self-administered significantly less methamphetamine compared to the methamphetamine only group. For our extinction/reinstatement experiment, concurrent access to sucrose during self-regulated methamphetamine reinstatement reduced methamphetamine intake and non-reinforced methamphetamine-seeking behavior in rats compared to rats that received access to just methamphetamine. These findings indicate that concurrent access to alternative reinforcers during various stages of methamphetamine-seeking behavior robustly decreased methamphetamine intake and serves as a valid rodent choice paradigm.
机译：对滥用药物和寻求替代性非药物强化剂之间的选择作用的研究受到了越来越多的关注。对影响药物和替代增强剂之间选择的决定因素的理解最终将导致对药物改变的大脑的神经基质的理解。我们调查了在路易斯大鼠灭绝训练后同时使用蔗糖颗粒对甲基苯丙胺自我给药和甲基苯丙胺自我调节恢复的影响。我们的自我给药实验结果表明，与仅使用甲基苯丙胺组相比，同时使用蔗糖的大鼠自我给药的甲基苯丙胺明显更少。对于我们的灭绝/恢复实验，与仅接受甲基苯丙胺的大鼠相比，在自我调节的甲基苯丙胺恢复期间同时获取蔗糖减少了大鼠甲基苯丙胺的摄入和非强化的甲基苯丙胺寻找行为。这些发现表明，在甲基苯丙胺寻求行为的各个阶段中，同时使用替代补强剂可显着减少甲基苯丙胺的摄入，并可以作为有效的啮齿动物选择范例。

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