• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Early postnatal stress alters the extinction of context-dependent conditioned fear in adult rats.
【24h】

Early postnatal stress alters the extinction of context-dependent conditioned fear in adult rats.

机译：出生后的早期应激改变成年大鼠中与情境有关的条件性恐惧的消失。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Fear extinction is hypothesized to be a learning process based on a new inhibitory memory. The present study was conducted to elucidate the effect of early postnatal stress on the extinction of context-dependent fear memory in adult rats, with a focus on the serotonergic system. Extinction was estimated by the expression of freezing behavior during repeated extinction trials (i.e., repeated exposure to contextual fear conditioning) on consecutive days. The decrease in fear expression was attenuated in adult rats that had been subjected to footshock (FS) at the third postnatal week (3wFS), but not in those exposed to footshock at the second postnatal week (2wFS). The decreased attenuation of freezing behavior observed in 3wFS was abolished by repeated treatment with the partial N-methyl-D-aspartate receptor agonist D-cycloserine (15 mg/kg, i.p., for 4 days), which has been shown to facilitate cue-dependent extinction. Repeated treatment with the serotonin 5-hydroxytryptamine-1A (5-HT(1A)) receptor agonist tandospirone (1 mg/kg, i.p., for 4 days) prevented the expression of freezing behavior in 3wFS, whereas diazepam treatment (1 mg/kg, i.p., for 4 days) in 3wFS did not. These results suggest that exposure to early postnatal stress at the third week is responsible for attenuating extinction of contextual fear conditioning and is mediated by a serotonergic 5-HT(1A) receptor mechanism. In other words, exposure to traumatic events during the early postnatal period might precipitate long-lasting alterations in synaptic function that underlie extinction processes of context-dependent fear memory.
机译：恐惧绝种被认为是基于新的抑制记忆的学习过程。进行本研究以阐明早期产后应激对成年大鼠情境依赖性恐惧记忆消失的影响，重点是血清素能系统。灭绝是通过连续几天反复灭绝试验（即反复暴露于情境恐惧条件）中的冰冻行为表达来估计的。在产后第三周（3wFS）遭受过脚电击（FS）的成年大鼠中，恐惧表达的减弱有所减弱，而在产后第二周（2wFS）遭受过脚电击的成年大鼠则没有这种恐惧表达。通过部分N-甲基-D-天冬氨酸受体激动剂D-环丝氨酸（15 mg / kg，腹膜内注射，持续4天）的重复处理，消除了3wFS中所观察到的冷冻行为减弱的减弱。依赖灭绝。血清素5-羟色胺1A（5-HT（1A））受体激动剂tandospirone（1 mg / kg，ip，4天）的重复治疗可防止3wFS的冰冻行为表达，而地西epa治疗（1 mg / kg ，ip，4天）在3wFS中没有。这些结果表明，在第三周暴露于产后早期应激是减轻背景恐惧条件消退的原因，并由5-羟色胺能5-HT（1A）受体机制介导。换句话说，在产后早期暴露于创伤事件可能会导致突触功能的长期变化，这是依赖于上下文的恐惧记忆消退过程的基础。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号