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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Differences in the behavioral time course of effects of rate-increasing and rate-decreasing doses of cocaine in pigeons.
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Differences in the behavioral time course of effects of rate-increasing and rate-decreasing doses of cocaine in pigeons.

机译：鸽子可卡因剂量增加和减少剂量作用的行为时间过程的差异。

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摘要

Although past research has examined the time course of plasma levels of cocaine in a variety of species, the time course of behavioral effects of cocaine on operant behavior has not been carefully described. The purpose of the present study was to examine the time course of effects of cocaine on operant behavior of pigeons, using a method that allowed comparison of dose-response functions, in individual subjects, within a session. Five pigeons responded under a multiple Fixed Interval 10 min Fixed Ratio 30 (FI 10 min FR 30) schedule of food presentation, with each component presented 10 times per session. Following acute administration, dose-response functions remained stable for about 45 min. Effects of acute cocaine administration also revealed that behavioral effects of large doses of cocaine diminished later in sessions, but effects were evident for at least 2 h. Exposure to chronic (i.e., daily) cocaine administration of a rate-decreasing dose led to tolerance that was characterized by diminished potency. Effects of formerly rate-decreasing doses diminishing earlier in the session compared to acute administration, and formerly rate-increasing doses resulted in rates similar to those under the saline-vehicle control from the session outset.
机译：尽管过去的研究已经检查了各种物种血浆中可卡因水平的时程，但尚未仔细描述可卡因对操作者行为的行为影响的时程。本研究的目的是使用可比较个体受试者剂量反应功能的方法，研究可卡因对鸽子操作行为的影响的时程。五只鸽子在多次固定间隔10分钟固定比率30（FI 10分钟FR 30）的食物展示计划下做出回应，每个环节每次展示10次。急性给药后，剂量反应功能保持稳定约45分钟。急性可卡因给药的作用还显示，大剂量可卡因的行为影响在疗程后期减弱，但效果持续至少2小时。长期（即每天）服用可卡因降低剂量的剂量会导致耐受性下降，其特征是效力降低。与急性给药相比，以前减量剂量的影响在治疗过程中较早减少，而以前减量剂量的作用与治疗开始时的生理盐水控制相似。

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