• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Locomotor stimulation produced by 3,4-methylenedioxymethamphetamine (MDMA) is correlated with dialysate levels of serotonin and dopamine in rat brain.
【24h】

Locomotor stimulation produced by 3,4-methylenedioxymethamphetamine (MDMA) is correlated with dialysate levels of serotonin and dopamine in rat brain.

机译：3,4-亚甲二氧基甲基苯丙胺（MDMA）产生的运动刺激与大鼠脑中血清素和多巴胺的透析液水平相关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

(+/-)-3,4-Methylenedioxymethamphetmine (MDMA, or Ecstasy) is an illicit drug that evokes transporter-mediated release of monoamines, including serotonin (5-HT) and dopamine (DA). Here we monitored the effects of MDMA on neurochemistry and motor activity in rats, as a means to evaluate relationships between 5-HT, DA, and behavior. Male rats undergoing in vivo microdialysis were housed in chambers equipped with photobeams for measurement of ambulation (i.e., forward locomotion) and stereotypy (i.e., head weaving and forepaw treading). Microdialysis probes were placed into the n. accumbens, striatum or prefrontal cortex in separate groups of rats. Dialysate samples were assayed for 5-HT and DA by microbore HPLC-ECD. Rats received two i.v. injections of MDMA, 1 mg/kg followed by 3 mg/kg 60 min later; neurochemical and locomotor parameters were measured concurrently. MDMA produced dose-related elevations in extracellular 5-HT and DA in all regions, with the magnitude of 5-HT release always exceeding that ofDA release. MDMA-induced ambulation was positively correlated with dialysate DA levels in all regions (P<0.05-0.0001) and with dialysate 5-HT in striatum and cortex (P<0.001-0.0001). Stereotypy was strongly correlated with dialysate 5-HT in all areas (P<0.001-0.0001) and with dialysate DA in accumbens and striatum (P<0.001-0.0001). These data support previous work and suggest the complex spectrum of behaviors produced by MDMA involves 5-HT and DA in a region- and modality-specific manner.
机译：（+/-）-3,4-亚甲二氧基甲基苯丙胺（MDMA或摇头丸）是一种非法药物，可引起转运蛋白介导的单胺释放，包括5-羟色胺（5-HT）和多巴胺（DA）。在这里，我们监测了MDMA对大鼠神经化学和运动活动的影响，以此作为评估5-HT，DA和行为之间关系的一种手段。将进行了体内微透析的雄性大鼠饲养在装有光射束的室中，以测量运动（即向前运动）和定型（即头部编织和前爪踩踏）。将微透析探针放入n。分开的大鼠群中的伏隔，纹状体或前额叶皮层。通过微孔HPLC-ECD分析透析液样品中的5-HT和DA。大鼠接受了两次静脉注射注射1 mg / kg的MDMA，然后在60分钟后注射3 mg / kg;同时测量神经化学和运动参数。 MDMA在所有区域都导致细胞外5-HT和DA的剂量相关升高，其中5-HT释放的幅度总是超过DA释放的幅度。 MDMA引起的移动与所有区域的透析液DA水平呈正相关（P <0.05-0.0001），纹状体和皮质的透析液5-HT呈正相关（P <0.001-0.0001）。刻板印象与所有区域的透析液5-HT密切相关（P <0.001-0.0001），与伏隔和纹状体的透析液DA密切相关（P <0.001-0.0001）。这些数据支持先前的工作，并表明由MDMA产生的行为的复杂范围涉及5-HT和DA的区域和模式特定方式。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号