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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Adrenalectomy potentiates the antinociceptive effects of calcium channel blockers.
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Adrenalectomy potentiates the antinociceptive effects of calcium channel blockers.

机译：肾上腺切除术增强钙通道阻滞剂的抗伤害感受作用。

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摘要

Calcium channel blockers can modulate the nociceptive threshold. However, the underlying mechanism(s), especially the role of hypothalamic-pituitary-adrenal (HPA) axis, on this effect has not yet been clarified. In the present study we investigated the analgesic effect of verapamil, diltiazem and nimodipine in intact and adrenalectomized (ADX) male rats and also measured the effect of these drugs on HPA function. The tail-flick and hot-plate tests were used to assess the nociceptive threshold before and 15, 30, 60 and 120 min after drug administration. Corticosterone level was measured by radioimmunoassay as a marker of HPA function. Our results showed that these drugs could elicit antinociceptive effects which were more prominent in the hot-plate than in the tail-flick tests. Following the exclusion of adrenal glands these drugs showed stronger analgesic effects. Acute administration of verapamil, diltiazem and nimodipine produced significant decrease in plasma corticosterone level that was more prominent by nimodipine. In conclusion, the results of our study show that the HPA function has an important role in the antinociceptive effect of calcium channel blockers.
机译：钙通道阻滞剂可以调节伤害阈值。但是，尚不清楚这种作用的潜在机制，尤其是下丘脑-垂体-肾上腺（HPA）轴的作用。在本研究中，我们研究了维拉帕米，地尔硫卓和尼莫地平在完整和肾上腺切除的（ADX）雄性大鼠中的镇痛作用，还测量了这些药物对HPA功能的作用。甩尾和热板试验用于评估在给药前和给药后15、30、60和120分钟的伤害感受性阈值。通过放射免疫测定法测定皮质酮水平作为HPA功能的标志。我们的结果表明，这些药物可引起抗伤害感受作用，在热板上比在甩尾试验中更显着。排除肾上腺后，这些药物显示出更强的镇痛作用。维拉帕米，地尔硫卓和尼莫地平的急性给药使血浆皮质酮水平显着下降，尼莫地平更为显着。总之，我们的研究结果表明，HPA功能在钙通道阻滞剂的抗伤害感受作用中具有重要作用。

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