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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Same-sex cohabitation under the effects of quinpirole induces a conditioned socio-sexual partner preference in males, but not in female rats.
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Same-sex cohabitation under the effects of quinpirole induces a conditioned socio-sexual partner preference in males, but not in female rats.

机译：在喹吡罗作用下的同性同居会在雄性大鼠中诱发条件性的性伴侣偏好，但在雌性大鼠中则不会。

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摘要

The effects of the dopamine D2-type receptor agonist quinpirole (QNP) were examined on the development of conditioned same-sex partner preference induced by cohabitation in rats. In Experiment 1, males received either saline or QNP (1.25mg/kg) and cohabited during three trials with almond-scented stimulus males that were sexually naive. In Experiment 2, males received six trials, and in Experiment 3 received three trials with sexually expert stimulus males. During a final drug-free preference test, males chose between the familiar or a novel male partner. In Experiments 1, 2 and 3 only QNP-treated males displayed a social preference for the familiar male, observed with more time spent together. In Experiment 3 males also displayed a sexual preference observed with more non-contact erections when were exposed to their male partner. In Experiment 4 we tested the effects on OVX, E+P primed females that received 1 systemic injection of either saline or QNP during three conditioning trials. In Experiment 5, females received 2 injections 12-h apart during each trial. Results indicated that both saline and QNP-treated females failed to develop partner preference. These data demonstrate that enhanced D2-type receptor activity during cohabitation facilitates the development of conditioned same-sex partner preference in males, but not in female rats. We discuss the implications for same-sex partner preferences.
机译：研究了多巴胺D2型受体激动剂喹吡罗（QNP）对同居诱导的条件性同性伴侣偏好发展的影响。在实验1中，男性接受了盐水或QNP（1.25mg / kg）的治疗，并在三项试验中与天真的性爱杏仁味刺激男性同居。在实验2中，男性接受了6次试验，在实验3中，对性专家刺激的男性进行了3次试验。在最终的无毒品偏好测试中，男性在熟悉的伴侣或新奇的男性伴侣之间进行选择。在实验1、2和3中，只有QNP处理的男性表现出对熟悉的男性的社交偏好，并且在一起度过的时间更多。在实验3中，与男性伴侣接触时，雄性也表现出性倾向，且非接触性勃起更多。在实验4中，我们在三个条件试验中测试了对接受1剂生理盐水或QNP全身注射的OVX，E + P致敏雌性的影响。在实验5中，雌性在每次试验中间隔12小时注射2次。结果表明，生理盐水和QNP处理的女性均未能发展伴侣的偏好。这些数据表明，在同居期间增强的D2型受体活性促进了雄性（而非雌性大鼠）条件性同性伴侣偏好的发展。我们讨论了同性伴侣偏好的含义。

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