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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Nicotine-induced plasma corticosterone is attenuated by social interactions in male and female adolescent rats.
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Nicotine-induced plasma corticosterone is attenuated by social interactions in male and female adolescent rats.

机译：尼古丁诱导的血浆皮质酮在男性和女性青春期大鼠中通过社交互动而减弱。

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Most smokers begin smoking during adolescence, a period during which social reward is highly influential. Initial exposure to nicotine can produce anxiogenic effects that may be influenced by social context. This study examined play behavior and plasma corticosterone following nicotine administration (0.6 mg/kg, s.c.) in both male and female adolescent (PND39) Sprague-Dawley rats in either isolate or social contexts. In blood samples collected immediately following the 15-min test session, nicotine increased plasma corticosterone relative to saline in both male and female isolate rats, but failed to do so in both males and females placed together in same-sex pairs. Nicotine also attenuated several indices of play behavior including nape attacks, pins and social contact. In isolate rats, nicotine selectively increased locomotor activity in females; however, when administered to social pairs, nicotine decreased locomotion in both sexes. These findings suggest that the presence of a social partner may decrease the initial negative, stress-activating effects of nicotine, perhaps leading to increased nicotine reward.
机译：大多数吸烟者在青春期开始吸烟，在这段时期内，社交奖励具有很大的影响力。最初接触尼古丁会产生焦虑效应，可能会受到社会环境的影响。这项研究研究了在单独或社交场合下在雄性和雌性（PND39）Sprague-Dawley大鼠中服用尼古丁（0.6 mg / kg，皮下）尼古丁给药后的游戏行为和血浆皮质酮。在15分钟的测试后立即采集的血液样本中，尼古丁相对于生理盐水在雄性和雌性隔离大鼠中均使血浆皮质酮水平升高，但在同性对中雄性和雌性中均没有这样做。尼古丁还减弱了一些游戏行为指标，包括项背攻击，发夹和社交接触。在分离的大鼠中，尼古丁有选择地增加雌性的自发活动。但是，当与社会人士一起使用时，尼古丁会降低男女的运动能力。这些发现表明，社交伙伴的存在可能会减少尼古丁最初的负面，压力激活作用，可能导致尼古丁报酬增加。

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