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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Spatiotemporal properties of locomotor activity after administration of central nervous stimulants and sedatives in mice.
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Spatiotemporal properties of locomotor activity after administration of central nervous stimulants and sedatives in mice.

机译：小鼠中枢神经兴奋剂和镇静剂给药后运动活动的时空特性。

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In the present study, we investigated the spatiotemporal properties of locomotor activity after administration of CNS sedatives (pentobarbital and diazepam) and stimulants (theophylline and caffeine) in an open field test. The absolute and relative distances traveled in central or peripheral regions within 2 h were analyzed. We found that both pentobarbital and diazepam increased total travel distances, especially within the initial 30 min, when traveling was mainly in the peripheral region. Pentobarbital induced this hyperactivity at higher doses (maximum at 30 mg/kg); while diazepam at higher doses (4 and 8 mg/kg) mainly decreased the traveled distance during 0-1 h but increased that in the periphery during 1-2 h. On the other hand, both theophylline and caffeine generally increased the traveled distance in the central region; this effect lasted longer with increasing dose. Caffeine increased the traveled distance at lower doses (maximum at 10 mg/kg) but decreased it at higher doses (30 and 100 mg/kg) during the initial 1 h. Theophylline exhibited a similar but smaller decrease at higher doses. Thus, we revealed the spatiotemporal properties that sedatives decrease central locomotion but induce a dose-related peripheral hyperactivity while stimulants induce central hyperactivity with a bell-shaped dose-response relation.
机译：在本研究中，我们在露天试验中研究了中枢神经系统镇静剂（戊巴比妥和地西epa）和兴奋剂（茶碱和咖啡因）给药后运动活动的时空特性。分析了2小时内在中心或外围区域中经过的绝对距离和相对距离。我们发现，戊巴比妥和地西epa均增加了总旅行距离，尤其是在最初的30分钟内，主要是在周边地区旅行。戊巴比妥以较高剂量（最大剂量为30 mg / kg）引起这种多动。地西epa在较高剂量（4和8 mg / kg）下主要在0-1小时内减少了行进距离，但在1-2小时内增加了行进距离。另一方面，茶碱和咖啡因通常会增加中部区域的行进距离。随着剂量增加，这种作用持续更长的时间。咖啡因在最初的1小时内以较低的剂量（最大10 mg / kg）增加了行进距离，但以较高的剂量（30和100 mg / kg）减少了行进距离。茶碱在较高剂量下表现出相似但较小的下降。因此，我们揭示了时空特性，镇静剂降低中心运动，但引起剂量相关的外周过度活跃，而兴奋剂以钟形剂量反应关系诱导中心过度活跃。

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