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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >A high fructose diet does not affect amphetamine self-administration or spatial water maze learning and memory in female rats.
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A high fructose diet does not affect amphetamine self-administration or spatial water maze learning and memory in female rats.

机译：高果糖饮食不会影响雌性大鼠的苯丙胺自我给药或空间水迷宫学习和记忆。

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High energy diets can have a detrimental effect on brain plasticity. For example, a high fructose diet impairs spatial memory in male rats. The aim of the present study was to determine whether a high fructose diet impairs another form of learning and memory: drug reinforcement learning. Female Sprague-Dawley rats were fed a high fructose diet (60%) from weaning at postnatal day (PND) 21, then allowed to acquire lever-pressing maintained by intravenous (i.v.) amphetamine at PND 68, 109, or 165. Acquisition was tested on a fixed ratio one (FR1) schedule of reinforcement (0.025 mg/kg/infusion, 1h daily sessions, 10 sessions over 14 days), followed by testing for reinforcing efficacy on a progressive ratio (PR) schedule (0.025, 0.01, and 0.1mg/kg/infusion), 14 days of abstinence, and within-session extinction and reinstatement tests. Subsequently, water maze acquisition and retention were tested in these subjects as well as a separate cohort tested in the water maze only. The diet had no effect on acquisition, reinforcing efficacy, extinction, or reinstatement of amphetamine seeking. Nor did the diet alter any measures of spatial memory. The high fructose diet did decrease body mass and increase relative liver and spleen mass, but did not affect plasma triglyceride concentrations consistently. Together with prior research on males, these results suggest that the metabolism of fructose and the effects of a high fructose diet on learning and memory may be sex-dependent.
机译：高能量饮食会对大脑可塑性产生不利影响。例如，高果糖饮食会损害雄性大鼠的空间记忆。本研究的目的是确定高果糖饮食是否会损害另一种形式的学习和记忆：药物强化学习。在出生后第21天（PND）断奶时，给雌性Sprague-Dawley大鼠喂高果糖饮食（60％），然后通过静脉内（iv）苯丙胺苯丙胺（PND）68、109或165维持杠杆压迫。在固定比例的一项强化治疗（FR1）计划中进行测试（0.025 mg / kg /输液，每天1h，在14天中进行10次疗程），然后在进行性比例（PR）计划中测试增强功效（0.025，0.01，和0.1mg / kg /滴注），禁欲14天以及疗程内的消光和恢复原状测试。随后，在这些对象中测试了水迷宫的获取和保留，以及仅在水迷宫中测试了一个单独的队列。饮食对寻求苯丙胺的获取，增强功效，灭绝或恢复没有影响。饮食也没有改变任何空间记忆指标。高果糖饮食确实降低了体重，增加了相对的肝脏和脾脏质量，但并未持续影响血浆甘油三酯的浓度。与先前对男性的研究一起，这些结果表明果糖的代谢以及高果糖饮食对学习和记忆的影响可能与性别有关。

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