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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Anxiety-like behaviors and expression of SERT and TPH in the dorsal raphe of estrogen- and fluoxetine-treated ovariectomized rats.
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Anxiety-like behaviors and expression of SERT and TPH in the dorsal raphe of estrogen- and fluoxetine-treated ovariectomized rats.

机译：雌激素和氟西汀治疗去卵巢大鼠的背缝中焦虑样行为和SERT和TPH的表达。

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摘要

The anxiolytic effect of fluoxetine (Flx) was often ineffective in postmenopausal and estrogen-deficient patients, but such effect had not been experimentally demonstrated, particularly in the female rat model of estrogen deficiency. Here we determined the anxiety-like behaviors in ovariectomized (Ovx) rats treated for 4weeks with 10mug/kg 17beta-estradiol s.c. (Ovx+E2), 10mg/kg Flx p.o. (Ovx+Flx) or a combination of both (Ovx+E2+Flx). Since Flx is known to induce anxiolysis in males, we first evaluated the Flx regimen in male rats. The results showed that anxiety-like behaviors were reduced in Flx-treated male rats. In contrast, Ovx+Flx rats still exhibited the same anxiety-like behaviors as in Ovx rats. Both Ovx+E2 and Ovx+E2+Flx rats, however, showed comparable reductions in anxiety-like behaviors, suggesting that Flx had no anxiolytic-like effect. Furthermore, E2 and E2+Flx similarly upregulated the mRNA expression of serotonin reuptake transporter (SERT) and tryptophan hydroxylase-2 in the dorsal raphe of Ovx rats, while having no effect on SERT expression in the frontal cortex, hippocampus, septum, amygdala and periaqueductal gray. In conclusion, Flx induced anxiolytic-like action in male rats. In Ovx rats, it was E2 and not Flx that exerted the anxiolytic-like action, which was mediated, in part, by altering serotonin metabolism in the dorsal raphe.
机译：氟西汀（Flx）的抗焦虑作用在绝经后和雌激素缺乏的患者中通常无效，但是这种作用尚未得到实验证明，尤其是在雌性雌激素缺乏的大鼠模型中。在这里，我们确定了用10mug / kg 17beta-雌二醇s.c治疗4周的去卵巢（Ovx）大鼠的焦虑样行为。 （Ovx + E2），每次点注10mg / kg Flx。 （Ovx + F1x）或两者的组合（Ovx + E2 + F1x）。由于已知Flx会诱导雄性焦虑，因此我们首先评估了雄性大鼠的Flx方案。结果表明，在Flx处理的雄性大鼠中，焦虑样行为减少。相反，Ovx + Flx大鼠仍表现出与Ovx大鼠相同的焦虑样行为。然而，Ovx + E2和Ovx + E2 + Flx大鼠均表现出类似的焦虑样行为减少，表明Flx没有抗焦虑样作用。此外，E2和E2 + Flx同样上调了Ovx大鼠背脊中5-羟色胺再摄取转运蛋白（SERT）和色氨酸羟化酶2的mRNA表达，而对额叶皮层，海马，隔膜，杏仁核和杏仁核中的SERT表达没有影响。导水管周围的灰色。总之，Flx诱导了雄性大鼠的抗焦虑样作用。在Ovx大鼠中，E2而非Flx发挥了抗焦虑样作用，其作用部分是通过改变背缝中5-羟色胺的代谢来实现的。

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