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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Similar anxiety-like responses in male and female rats exposed to repeated withdrawals from ethanol.
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Similar anxiety-like responses in male and female rats exposed to repeated withdrawals from ethanol.

机译：暴露于乙醇反复停药的雄性和雌性大鼠中，类似的焦虑样反应。

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Previous research indicated that male rats exhibited anxiety-like behavior following withdrawal from chronic ethanol exposure. This behavior, as well as other symptoms of withdrawal such as seizure susceptibility, may be sensitized in male rats repeatedly withdrawn from chronic ethanol exposure. Because there are sex differences in some alcohol effects, the present study explored whether male and female rats would respond differently to a course of repeated ethanol withdrawals. Similarly aged male and female rats were exposed to a control liquid diet or a diet containing ethanol (7% w/v). Ethanol-exposed rats had only one 5-day cycle of exposure or three cycles, with 2 days of control diet (CD) between cycles. At 5 h after the final ethanol was removed, the rats were placed as same-sexed pairs in the social interaction test; approximately half of the rats were tested later in the elevated plus maze. Rats withdrawn from ethanol after three cycles exhibited reduced the time spent in social interaction and general activity in the social interaction test and reduced the open and closed arm entries in the elevated plus maze. There were no sex differences in these effects. However, male rats exhibited a small anxiety-like response after one cycle of 5 days' exposure to ethanol and female rats did not. Thus, there are no sex differences in the three-cycle multiple-withdrawal paradigm, but there may be differences after briefer exposures.
机译：先前的研究表明，雄性大鼠退出慢性乙醇暴露后表现出焦虑样行为。这种行为以及其他戒断症状，​​例如癫痫发作易感性，可能会在长期暴露于长期乙醇的雄性大鼠中变得敏感。由于某些酒精效应存在性别差异，因此本研究探讨了雄性和雌性大鼠对反复戒断乙醇的反应是否有所不同。类似地，将成年的雄性和雌性大鼠暴露于对照流质饮食或含乙醇（7％w / v）的饮食。暴露于乙醇的大鼠只有一个5天的暴露周期或三个周期，两个周期之间有2天的对照饮食（CD）。除去最终的乙醇后5小时，将大鼠以同性配对的方式放置在社交互动测试中。大约一半的大鼠稍后在高架迷宫中进行测试。在三个周期后从乙醇中撤出的大鼠表现出减少了在社交互动测试中花费在社交互动和一般活动上的时间，并减少了高架迷宫中打开和闭合手臂的进入。这些作用没有性别差异。然而，雄性大鼠在暴露于乙醇的5天的一个周期后表现出小的焦虑样反应，而雌性大鼠则没有。因此，三周期多次退出范式中没有性别差异，但是短暂接触后可能会有差异。

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