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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of the 5-HT1A antagonist (+)-WAY-100135 on murine social and agonistic behavior.
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Effects of the 5-HT1A antagonist (+)-WAY-100135 on murine social and agonistic behavior.

机译：5-HT1A拮抗剂（+）-WAY-100135对小鼠社交和激动行为的影响。

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摘要

Compounds previously identified as 5-HT1A antagonists have subsequently been demonstrated to possess partial agonistic properties in models assessing somatodendritic autoreceptor function. This study examined the influences of (+)-WAY-100135, claimed to be the first selective 5-HT1A antagonist, on offensive behaviour in male mice. Employing a resident-intruder paradigm, administration of (+)-WAY-100135 (1.0-10.0 mg/kg s.c.) enhanced elements of resident offensive behaviour at 2.5 and 5.0 mg/kg but reduced such behaviour at 10.0 mg/kg. In comparison, resident defensive postures remained unchanged except for a significant increase in defensive sideways behaviour at 10.0 mg/kg. These effects were accompanied by reduced rearing behaviour across the dose range tested. Attend/approach behaviour was significantly reduced at the lowest, but increased at the highest, doses tested. Such results may reflect response competition rather than concomitant motor impairment. Given the dynamic behavioural interactions occurring in this paradigm, the increased offensive behaviour of the resident mice leads to enhanced defence and counter-attack by the intruder conspecifics. The results are discussed with reference to the current literature concerning the behavioural effects of other 5-HT1A antagonists.
机译：随后已证明先前鉴定为5-HT1A拮抗剂的化合物在评估体树突状自身受体功能的模型中具有部分激动特性。这项研究检查了（+）-WAY-100135（据称是第一种选择性5-HT1A拮抗剂）对雄性小鼠攻击行为的影响。采用常驻入侵者范式，（+）-WAY-100135（1.0-10.0 mg / kg s.c.）的施用增强了2.5和5.0 mg / kg时居民攻击行为的要素，但在10.0 mg / kg时减少了这种行为。相比之下，居民的防御姿势保持不变，除了防御侧身行为明显增加（10.0 mg / kg）。这些影响伴随着在整个测试剂量范围内的饲养行为减少。出席/进场行为在最低的测试剂量下显着降低，但在最高的剂量下增加。这样的结果可能反映了反应竞争而不是伴随的运动障碍。考虑到在这种范式中发生的动态行为交互作用，常驻小鼠进攻行为的增加会导致入侵者的特定物种增强防御和反击能力。参考有关其他5-HT1A拮抗剂的行为效应的现有文献讨论了结果。

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