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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of chlorpromazine and diazepam on time estimation behavior and motivation in rats.
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Effects of chlorpromazine and diazepam on time estimation behavior and motivation in rats.

机译：氯丙嗪和地西epa对大鼠时间估计行为和动机的影响。

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摘要

The effects of chlorpromazine and diazepam on performance of two operant tasks, one modelling time estimation and the other motivation to work for food reinforcers, were investigated in rats. These same tasks had been used previously in rhesus monkeys to assess the effects of chlorpromazine and diazepam. Rat performance of the time estimation task [temporal response differentiation (TRD)] was nearly identical to that previously described in monkeys. This performance similarity across these two species occurred despite slightly different methodologies. Performance of the motivation task [progressive ratio (PR)] was clearly different between rats and adult monkeys in that rats exhibited lower values on all PR endpoints. Acute administration of chlorpromazine [0.03-5.6 mg/kg, intraperitoneally (IP)] caused decrements in rat TRD and PR performance at doses > or = 1.0 mg/kg. Acute administration of diazepam (0.25-4.0 mg/kg, IP) altered TRD performance only. The effects of chlorpromazine and diazepam in ratswere similar to those previously noted in the monkey, indicating the potential utility of rat performance in these operant tasks to predict drug effects in the rhesus monkey.
机译：在大鼠中研究了氯丙嗪和地西epa对两项操作任务执行的影响，一项是建模时间估计，另一项是为食物强化剂工作的动机。这些相同的任务以前曾在恒河猴中用于评估氯丙嗪和地西epa的作用。时间估计任务的大鼠表现[时间反应分化（TRD）]与猴子先前描述的几乎相同。尽管方法略有不同，但在这两个物种上仍存在这种性能相似性。在大鼠和成年猴子之间，动机任务[进步比率（PR）]的执行效果明显不同，因为大鼠在所有PR端点上均显示较低的值。大于或等于1.0 mg / kg的氯丙嗪[0.03-5.6 mg / kg，腹膜内（IP）]的急性给药会导致大鼠TRD和PR的性能下降。地西epa的急性给药（0.25-4.0 mg / kg，IP）仅改变TRD性能。氯丙嗪和地西epa对大鼠的作用与先前在猴子中提到的相似，表明大鼠在这些操作任务中的表现可能具有潜在的效用，以预测恒河猴的药物作用。

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