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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Functional neuroanatomy of the endocannabinoid system.
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Functional neuroanatomy of the endocannabinoid system.

机译：内源性大麻素系统的功能神经解剖学。

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摘要

Several components of the endocannabinoid system have been fully characterized. Among them are two types of cannabinoid receptors (termed CB1 and CB2), endogenous ligands for those receptors (referred to as endocannabinoids degradation and inactivation. The study of the distribution and abundance of these elements in the central nervous system has provided the basis for the well-known effects of exogenous (both natural and synthetic) and endogenous cannabinoids. In addition, recent developments also support the idea that the endocannabinoid system plays a critical neuromodulatory role in the central nervous system. For instance, cannabinoid CB1 receptor activation is known to modify the release of several neurotransmitters, such as glutamate and gamma-aminobutyric acid. However, we still lack knowledge on fundamental aspects of the physiological roles of this system. Interestingly, changes in the distribution and activity of some of these components of the endocannabinoid system have been reported under different pathological conditions, suggesting their possible involvement in the pathogenesis of these diseases. As comprehensive excellent reviews have been recently published, the present review will focus only on the most recent advances in the field, considering a new perspective of the endocannabinoid system as composed of both neuronal and glial divisions.
机译：大麻素系统的几个组成部分已得到充分表征。其中有两种类型的大麻素受体（分别称为CB1和CB2），即这些受体的内源性配体（称为内源性大麻素降解和失活）。对这些元素在中枢神经系统中的分布和丰度的研究为基础外源性（天然和合成）大麻素的众所周知的作用，此外，最近的进展也支持内源性大麻素系统在中枢神经系统中起关键的神经调节作用的观点，例如，已知大麻素CB1受体激活改变谷氨酸和γ-氨基丁酸等几种神经递质的释放，但是，我们仍然对该系统的生理作用的基本知识缺乏了解，有趣的是，内源性大麻素系统中某些成分的分布和活性发生了变化在不同的病理条件下已有报道，表明它们可能参与这些疾病的发病机理。由于最近已经发表了全面的优秀综述，因此本综述将仅关注该领域的最新进展，考虑到由神经元和神经胶质分裂组成的内源性大麻素系统的新观点。

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