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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Synergistic effect of decreased opioid activity and sleep deprivation on head-twitch response in mice.
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Synergistic effect of decreased opioid activity and sleep deprivation on head-twitch response in mice.

机译：阿片类药物活性降低和睡眠剥夺对小鼠头部抽搐反应的协同作用。

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摘要

In schizophrenia, an opioidergic understimulation and a decreased sleep duration are found. The pathogenic significance of these factors is unknown. The present study assessed the influence of the combination of the factors on serotonergic 2A (5-HT(2A)) receptors that are possibly related to psychosis development. 2,5-dimethoxy-4-iodoamphetamine (DOI)-induced head-twitch response in mice was used as a model of 5-HT(2A) receptor functioning. Mice underwent sleep deprivation and/or a blockade of opioidergic receptors with naloxone. To evaluate the involvement of 5-HT(2A) receptor in effects observed, animals were pretreated with MDL 100,907, a potent and selective antagonist of 5-HT(2A) receptor. As was found, 4h of sleep deprivation followed by administration of naloxone significantly increases the frequency of head twitches, with sleep deprivation and naloxone being ineffective alone. The action of the "sleep deprivation-opioid understimulation" combination is antagonized completely by MDL 100,907. Thus, some schizophrenia-associated factors can synergistically enhance the activity of 5-HT(2A) receptors. These results suggest the above factors being pathogenically relevant in schizophrenia.
机译：在精神分裂症中，发现了阿片类药物不足的刺激和睡眠时间减少。这些因素的致病意义尚不清楚。本研究评估了这些因素的组合对血清素2A（5-HT（2A））受体的影响，这可能与精神病的发展有关。 2,5-二甲氧基-4-碘安非他明（DOI）诱导的小鼠头抽搐反应被用作5-HT（2A）受体功能的模型。小鼠接受了纳洛酮的睡眠剥夺和/或阿片类药物受体的阻断。为了评估5-HT（2A）受体在所观察到的效应中的参与，用MDL 100,907（一种有效且选择性的5-HT（2A）受体拮抗剂）对动物进行了预处理。如发现的那样，剥夺睡眠4小时后再施用纳洛酮显着增加了头部抽搐的频率，剥夺睡眠和纳洛酮单独无效。 MDL 100,907完全抵消了“睡眠剥夺-阿片类药物刺激不足”的作用。因此，一些精神分裂症相关的因素可以协同增强5-HT（2A）受体的活性。这些结果表明上述因素在精神分裂症中具有致病性。

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