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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Kainate microinjection into the dorsal raphe nucleus induces 5-HT release in the amygdala and periaqueductal gray.
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Kainate microinjection into the dorsal raphe nucleus induces 5-HT release in the amygdala and periaqueductal gray.

机译：海藻酸盐显微注射到背缝核中，会在杏仁核和导水管周围的灰色区域释放5-HT。

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Earlier results obtained in one of our laboratories showed that microinjection into the dorsal raphe nucleus (DRN) of the excitatory amino acid kainic acid, the benzodiazepine (BZD) inverse agonist FG 7142, and the 5-HT1A receptor agonist 8-OHDPAT changed the behavior of rats in the elevated T-maze, an animal model of anxiety. The present study investigates biochemical correlates of these results in awake rats by measuring 5-HT release with in vivo microdialysis in two brain structures innervated by the DRN-the amygdala (Am) and the dorsal periaqueductal gray matter (DPAG)-that have been implicated in anxiety. Microinjection of kainic acid (60 pmol) into the DRN significantly increased 5-HT release in both the Am and the DPAG. In the DPAG, the increase was 14-fold higher with respect to the baseline and occurred only at the first sample, which was collected 30 min after the injection. In the Am, the increase was less pronounced (nearly fourfold) but persistent, lasting until the fourth sample, which was collected 120 min from the injection. FG 7142 (40 pmol) and 8-OH-DPAT (8 nmol) were ineffective. Because only intra-DRN kainate both increased inhibitory avoidance and decreased one-way escape in the elevated T-maze, the present behavioral results support the suggestion that 5-HT facilitates conditioned fear in the Am and inhibits unconditioned fear in the DPAG.
机译：在我们的一个实验室中获得的较早结果表明，向兴奋性氨基酸红藻酸，苯二氮卓（BZD）反向激动剂FG 7142和5-HT1A受体激动剂8-OHDPAT的背缝核（DRN）显微注射改变了行为在升高的T型迷宫（一种焦虑症动物模型）中的老鼠数量。本研究通过测量5-HT的释放，并通过体内微透析研究了DRN支配的两个脑结构（杏仁核（Am）和背导水周灰质（DPAG））中这些结果的生物化学相关性，这些神经结构被牵连。在焦虑中。在DRN中微量注射海藻酸（60 pmol）可以显着增加Am和DPAG中的5-HT释放。在DPAG中，增加量相对于基线高14倍，并且仅在注射后30分钟收集的第一个样品中发生。在Am中，这种增加不太明显（几乎是四倍），但持续存在，一直持续到第四个样品（从注射开始120分钟收集）。 FG 7142（40 pmol）和8-OH-DPAT（8 nmol）无效。因为仅DRN内部的空灵酸盐在升高的T-迷宫中增加了抑制回避作用并减少了单向逃逸，所以目前的行为结果支持了5-HT促进Am中的条件性恐惧并抑制DPAG中的条件性恐惧的建议。

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