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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Adolescent cannabinoid exposure attenuates adult female sexual motivation but does not alter adulthood CB(1)R expression or estrous cyclicity.
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Adolescent cannabinoid exposure attenuates adult female sexual motivation but does not alter adulthood CB(1)R expression or estrous cyclicity.

机译：青春期大麻素暴露会减弱成年女性的性动机，但不会改变成年期CB（1）R的表达或发情周期。

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摘要

Adolescence is a developmental period characterized by neuronal remodeling and the maturation of adult emotionality, reproductive behavior and social behavior. We examined whether chronic cannabinoid exposure in adolescent rats alters female sexual motivation, estrous cyclicity, sucrose preference, and CB(1)R expression in adulthood. Female rats were administered with the synthetic cannabinoid agonist, CP-55,940 (0.4 mg/kg, intraperitoneal), daily during adolescent development (PND 35-45). In a subset of subjects, socio-sexual motivation was investigated in adulthood (PND 75-86) using a runway apparatus. Estrous cyclicity was tracked in adulthood via vaginal cytology and a single-mount test. A two-bottle sucrose preference test was also conducted to determine whether predicted changes in socio-sexual motivation might be linked to alterations in hedonic processing. CB(1)R expression was examined in two separate subsets of subjects, one sacrificed following drug treatment (PND 46) and one before behavioral testing (PND 74). Drug treatment significantly decreased adult preference for a male conspecific (sexual motivation), as assessed by both Run Time and Proximity Time, but did not affect estrous cyclicity or sucrose preference. CP-55,940 treatment also induced immediate, but transient, decreases in CB(1)R expression in the ventromedial nucleus of the hypothalamus and amygdala. Drug treatment did not affect CB(1)R expression in the nucleus accumbens (core or shell) or globus pallidus at either time point. We suggest that the endocannabinoid system may play a role in the maturation of neuroendocrine axes and adult female reproductive behavior, and that chronic exposure to cannabinoids during adolescence disrupts these neurodevelopmental processes.
机译：青春期是一个发育阶段，其特征是神经元重塑以及成人情绪，生殖行为和社交行为的成熟。我们检查了青春期大鼠中的慢性大麻素暴露是否会改变女性的性动机，发情的周期性，蔗糖偏爱和成年期的CB（1）R表达。在青春期发育期间（PND 35-45），每天向雌性大鼠施用合成大麻素激动剂CP-55,940（0.4 mg / kg，腹膜内）。在一部分受试者中，使用跑道装置在成年期（PND 75-86）调查了社会性动机。成年期的发情周期通过阴道细胞学检查和单次试验进行追踪。还进行了两瓶蔗糖偏爱测试，以确定社会性别动机的预测变化是否可能与享乐主义加工的改变有关。在两个单独的受试者亚组中检查了CB（1）R的表达，一个在药物治疗后被处死（PND 46），另一个在行为测试之前被处死（PND 74）。通过运行时间和接近时间评估，药物治疗显着降低了成年男性对男性特定性的偏好（性动机），但并未影响发情周期或蔗糖偏好。 CP-55,940处理还诱导下丘脑和杏仁核腹侧核中CB（1）R表达的立即但短暂的降低。在任一时间点，药物治疗均不影响伏隔核（核或壳）或苍白球中的CB（1）R表达。我们建议，内源性大麻素系统可能在神经内分泌轴的成熟和成年女性的生殖行为中起作用，并且青春期期间长期暴露于大麻素会破坏这些神经发育过程。

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