• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Attenuation of apomorphine-induced sensitization by buspirone.
【24h】

Attenuation of apomorphine-induced sensitization by buspirone.

机译：丁螺环酮对阿扑吗啡诱导的致敏作用的减弱。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Apomorphine, a dopamine D/D agonist is effective in the treatment of parkinson's disease; but its long term use is often associated with the dependence and addiction. The development of locomotor sensitization to psychostimulants including apomorphine is considered to be an important contributor to psychostimulant drug abuse. Previous studies have shown that long term administration of drugs of abuse increases the effectiveness of somatodendritic 5-hydroxytryptamine (5-HT)-1A receptors. Repeated administration of buspirone attenuates the effectiveness of somatodendritic 5-HT(1A) receptors. The present study was designed to test the hypothesis that coadministration of buspirone may attenuate apomorphine induced sensitization. Administration of apomorphine at a dose of 1.0, 2.0 & 4.0mg/kg increased motor activity in an activity box in a dose dependent manner. Locomotor enhancing effects of a low dose of apomorphine were augmented upon repeated administration suggesting drug-induced sensitization. The sensitization effects were significant in an activity box as well as in an open field. Coadministration of buspirone at a dose of 1.0mg/kg reversed apomorphine-induced sensitization. Repeated administration of buspirone at a dose of 2.0 mg/kg but not 1.0 mg/kg also elicited sensitization in motor behavior. It is suggested that buspirone may oppose the development of sensitization to apomorphine by decreasing the sensitivity of somatodendritic 5-HT(1A) receptors. Findings may help in extending therapeutics in parkinson's disease.
机译：阿扑吗啡是一种多巴胺D / D激动剂，可有效治疗帕金森氏病;但长期使用常常与依赖和成瘾有关。对包括阿扑吗啡在内的精神兴奋剂的运动致敏作用的发展被认为是精神兴奋剂药物滥用的重要原因。先前的研究表明，长期服用滥用药物会增加树突状5-羟色胺（5-HT）-1A受体的有效性。重复给予丁螺环酮会减弱体树突状5-HT（1A）受体的有效性。本研究旨在测试以下假设：丁螺环酮并用可能会减弱阿扑吗啡引起的致敏作用。在活动箱中以1.0、2.0和4.0mg / kg的剂量服用阿扑吗啡可增加剂量依赖性的运动活动。低剂量阿扑吗啡的运动增强作用在重复给药后增强，提示药物诱导的致敏作用。敏化作用在活动箱内以及在旷野中均很显着。以1.0mg / kg的剂量共同使用丁螺环酮可逆转阿扑吗啡引起的致敏作用。以2.0 mg / kg的剂量重复施用丁螺环酮而不是1.0 mg / kg的剂量也引起运动行为增敏。建议丁螺环酮可能会通过降低体树突状5-HT（1A）受体的敏感性来对抗对阿扑吗啡致敏的发展。这些发现可能有助于扩展帕金森氏病的治疗方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号