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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Combined effects of acute, very-low-dose ethanol and delta(9)-tetrahydrocannabinol in healthy human volunteers.
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Combined effects of acute, very-low-dose ethanol and delta(9)-tetrahydrocannabinol in healthy human volunteers.

机译：急性，超低剂量乙醇和delta（9）-tetrahydrocannabinol在健康人类志愿者中的联合作用。

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RATIONALE: Previous studies examining the combined effects of ethanol and cannabis, or its primary psychoactive ingredient, -tetrahydrocannabinol (THC), have provided mixed results. Data from an in vitro study suggests that combined, sub-threshold doses of these drugs may interact to produce synergistic effects. Very low doses of the two drugs in combination have not been tested in humans. MATERIALS AND METHODS: This study assessed whether combinations of acute, very low doses of ethanol and THC produce synergistic effects on subjective, cognitive, and physiological measures. Healthy volunteers (n=11) received capsules containing placebo or THC (2.5 mg), and beverages containing placebo or ethanol (0.1 and 0.2 g/kg) alone, and in combination, across separate sessions, in a within-subjects, randomized, double-blind design. During each session, participants completed measures of working memory, psychomotor ability, and simple reaction time, and provided subjective mood and drug effect ratings. Cardiovascular measures were obtained at regular intervals. RESULTS: As intended, when administered alone, these very low doses of ethanol and THC had only moderate effects on isolated measures. The combined effects of these drugs were not synergistic, and in some cases appeared to be less-than-additive. CONCLUSIONS: Our data provide no evidence for synergistic effects of acute combinations of very-low-dose ethanol and THC on subjective or physiologic response, or on cognitive performance.
机译：理由：先前研究了乙醇和大麻或其主要精神活性成分四氢大麻酚（THC）的联合作用的研究，得出的结果不一。一项体外研究的数据表明，这些药物的联合，低于阈值的剂量可能相互作用产生协同效应。尚未在人体中测试两种药物合用的极低剂量。材料与方法：这项研究评估了急性，极低剂量的乙醇与四氢大麻酚的组合是否对主观，认知和生理指标产生协同作用。健康志愿者（n = 11）分别接受不同剂量的安慰剂或THC（2.5 mg）胶囊，以及安慰剂或乙醇（0.1和0.2 g / kg）的饮料，这些药物分别在不同的疗程中随机分组，双盲设计。在每节课中，参与者完成了对工作记忆，精神运动能力和简单反应时间的测量，并提供了主观情绪和药物效果评分。定期获取心血管指标。结果：如预期的那样，当单独给药时，这些极低剂量的乙醇和四氢大麻酚仅对单独的措施有中度影响。这些药物的联合作用没有协同作用，在某些情况下似乎不及加和作用。结论：我们的数据没有提供证据表明极低剂量乙醇和四氢大麻酚的急性组合对主观或生理反应或认知表现有协同作用。

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