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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Gastroprotective and antidepressant effects of a new zinc(II)-curcumin complex in rodent models of gastric ulcer and depression induced by stresses.
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Gastroprotective and antidepressant effects of a new zinc(II)-curcumin complex in rodent models of gastric ulcer and depression induced by stresses.

机译：新型锌（II）-姜黄素复合物在应激引起的胃溃疡和抑郁的啮齿动物模型中的胃保护和抗抑郁作用。

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摘要

Curcumin, a yellow pigment found in the rhizome of Curcuma loga, has been used to treat a variety of digestive and neuropsychiatric disorders since ancient times in China. Curcumin can chelate various metal ions to form metallocomplexes of curcumin which show greater effects than curcumin alone. This study investigated the antiulcerogenic and antidepressant effects of a Zn(II)-curcumin complex on cold-restraint stress (CRS)-induced gastric ulcers in rats, and on the forced swimming test (FST), tail suspension test (TST) and 5-hydroxy-l-tryptophan (5-HTP)-induced head twitch test in mice. CRS disrupted the rat mucosal barrier and induced gastric ulcers by decreasing the activities of the antioxidant enzymes, and increasing H(+)-K(+)-ATPase activity and malondialdehyde (MDA) level. Pretreatment with Zn(II)-curcumin (12, 24, and 48mg/kg) dose-dependently reversed these trends, reduced gastric lesions and H(+)-K(+)-ATPase activity, and increased antioxidant activities compared with control groups. Zn(II)-curcumin significantly increased HSP70 mRNA, and attenuated increased iNOS mRNA in the mucosa. Zn(II)-curcumin (17, 34, and 68mg/kg) also significantly decreased immobility time in the FST and TST, and enhanced 5-HTP-induced head twitches in mice. These results demonstrate that the Zn(II)-curcumin complex showed significant gastroprotective and antidepressant effects compared with curcumin alone via a synergistic effect between curcumin and zinc.
机译：姜黄素是一种在姜黄根茎中发现的黄色颜料，自中国古代开始就被用于治疗各种消化系统疾病和神经精神疾病。姜黄素可以螯合各种金属离子，形成姜黄素的金属配合物，其作用比单独的姜黄素要强。这项研究调查了Zn（II）-姜黄素复合物对大鼠冷约束应激（CRS）诱发的胃溃疡的抗溃疡和抗抑郁作用，以及对强迫游泳测试（FST），尾部悬吊测试（TST）和5 -羟基-1-色氨酸（5-HTP）诱导的小鼠头部抽搐试验。 CRS通过降低抗氧化酶的活性，并增加H（+）-K（+）-ATPase活性和丙二醛（MDA）水平来破坏大鼠粘膜屏障并诱发胃溃疡。与对照组相比，锌（II）-姜黄素（12、24和48mg / kg）的剂量依赖性逆转了这些趋势，减少了胃部病变和H（+）-K（+）-ATPase活性，并增加了抗氧化剂活性。锌（II）姜黄素显着增加粘膜中的HSP70 mRNA，并减弱iNOS mRNA的表达。锌（II）-姜黄素（17、34和68mg / kg）还显着减少了FST和TST中的固定时间，并增强了小鼠的5-HTP诱导的头部抽搐。这些结果表明，与单独的姜黄素相比，Zn（II）-姜黄素复合物通过姜黄素和锌之间的协同作用显示出显着的胃保护和抗抑郁作用。

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