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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of chronic estradiol or testosterone treatment upon sexual behavior in sexually sluggish male rats
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Effects of chronic estradiol or testosterone treatment upon sexual behavior in sexually sluggish male rats

机译：慢性雌二醇或睾丸激素治疗对性迟缓雄性大鼠性行为的影响

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Sexually sluggish (SS) male rats represent a small proportion of animals that take a long time to ejaculate, or sometimes they do not ejaculate, when tested on repeated occasions with sexually receptive females. The current study was done in order to evaluate whether chronic estradiol (E 2) or testosterone (T) treatment could induce consistent ejaculatory behavior in these male rats. Those males that displayed sexual behavior but did not ejaculate in at least four of five tests were classified as SS and included in the present experiment. They were implanted subcutaneously with Silastic capsules that were empty or filled with E 2 or T. Starting one week after the implant, subjects were tested weekly with sexually receptive females for seven consecutive weeks. At the end of the experiment all subjects were weighed and sacrificed to weigh the accessory sex glands. The results showed that SS males implanted with an empty or T-filled capsule remained as such; they displayed mounts and intromissions but not a consistent pattern of ejaculation despite the twelve weeks of testing (5 screening tests and 7 with the corresponding implant). In contrast, the percentage of SS males implanted with an E 2 capsule that displayed the ejaculatory pattern was significantly reduced. Subjects treated with E 2 also displayed a higher number of mounts than the empty capsule group during several weeks of testing. At the end of the experiment the weights of the body, testicles, epididymis, seminal vesicles, and prostate of the SS male rats chronically treated with E 2 were lower than those of the empty or T capsule groups. In addition, male rats with a T implant showed lower testicular weight than the empty capsule group. These results suggest that the lack of ejaculation patter in SS male rats is not due to estrogenic or androgenic alteration.
机译：反复接受性接受雌性动物测试后，性呆滞（SS）雄性大鼠只占小部分动物的射精时间，或者长时间不射精。目前的研究是为了评估慢性雌二醇（E 2）或睾丸激素（T）治疗是否可以在这些雄性大鼠中诱导一致的射精行为。在五项测试中至少有四项表现出性行为但未射精的男性被列为SS，并包括在本实验中。他们被皮下植入空或充满E 2或T的Silastic胶囊。从植入后一周开始，每周对受试者进行性爱接受测试，连续七个星期。在实验结束时，将所有受试者称重并处死以称量附属性腺。结果表明，植入了空胶囊或T填充胶囊的SS雄性保持原样;尽管进行了十二周的测试（5次筛查和7次使用相应的植入物），他们仍表现出坐骑和前倾，但并没有一致的射精模式。相反，植入了表现出射精模式的E 2胶囊的SS男性的百分比显着降低。在几周的测试中，用E 2治疗的受试者的坐骑次数也比空胶囊组高。在实验结束时，用E 2长期治疗的SS雄性大鼠的体重，睾丸，附睾，精囊和前列腺的重量均低于空胶囊或T胶囊组。此外，植入T型雄性大鼠的睾丸重量低于空胶囊组。这些结果表明SS雄性大鼠中缺乏射精模式不是由于雌激素或雄激素改变。

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