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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >5-HT 1A receptor binding in the dorsal raphe nucleus is implicated in the anxiolytic-like effects of Cinnamomum cassia
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5-HT 1A receptor binding in the dorsal raphe nucleus is implicated in the anxiolytic-like effects of Cinnamomum cassia

机译：背叶核中的5-HT 1A受体结合与肉桂肉桂的抗焦虑作用有关

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摘要

Previously we reported that the 50% EtOH extract of Cinnamomum cassia (C. cassia) possesses anxiolytic-like activity in the mouse elevated plus maze (EPM) test. This activity was blocked by the 5-HT 1A receptor antagonist, WAY 100635. Therefore, in order to investigate the effect of C. cassia on 5-HT 1A receptor binding, quantitative autoradiography of 5-HT 1A receptors was carried out in brains of mice treated acutely and repeatedly with C. cassia. Binding of [ 3H]8-OH-DPAT to the 5-HT 1A receptor was investigated in the mouse brain. After a single treatment of C. cassia (750 mg/kg, p.o.), [ 3H]8-OH-DPAT binding showed a significant increase in the dorsal raphe nucleus (DRN). After repeated treatment with C. cassia (100 mg/kg, once a day for 5 days, p.o.), [ 3H]8-OH-DPAT binding showed no significant change in any brain region. Taken together, the anxiolytic-like effect of the 50% EtOH extract of C. cassia might be mediated by region specific change of 5-HT 1A receptors in the dorsal raphe nucleus.
机译：先前我们曾报道肉桂肉桂（C. cassia）的50％EtOH提取物在小鼠高架迷宫（EPM）测试中具有抗焦虑样活性。该活性被5-HT 1A受体拮抗剂WAY 100635阻断。因此，为了研究决明假单胞菌对5-HT 1A受体结合的影响，在大脑中对5-HT 1A受体进行了放射自显影。决明子急性和反复治疗小鼠。在小鼠脑中研究了[3H] 8-OH-DPAT与5-HT 1A受体的结合。在对决明子藻进行单次处理（750 mg / kg，p.o。）后，[3H] 8-OH-DPAT的结合显示背ra核（DRN）显着增加。在用决明子藻（100 mg / kg，每天一次，连续5天，口服）反复治疗后，[3H] 8-OH-DPAT结合在任何大脑区域均未显示明显变化。两者合计，肉桂的50％EtOH提取物的抗焦虑样作用可能是由背缝核中5-HT 1A受体的区域特异性变化介导的。

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