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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The anxiolytic effects of somatostatin following intra-septal and intra-amygdalar microinfusions are reversed by the selective sst2 antagonist PRL2903
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The anxiolytic effects of somatostatin following intra-septal and intra-amygdalar microinfusions are reversed by the selective sst2 antagonist PRL2903

机译：sst2拮抗剂PRL2903逆转了隔壁内和杏仁糖内微注射后生长抑素的抗焦虑作用

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摘要

Somatostatin (SST) is a polypeptide with two biological isoforms (SST14, and SST28), and five SST receptor subtypes (sst1-5). Together, they mediate a number of neural and hormonal functions. Recently, we found that intracerebroventricular (ICV), intra-amygdalar, and intra-septal microinfusions of SST14, SST28, and a selective sst2 receptor agonist L-779976 all produced anxiolytic-like effects in the elevated plus-maze, a widely used animal model of anxiety. The receptor specificity of these anxiolytic-like effects, however, has not been conclusively established. Accordingly, the anxiolytic effects of SST in the elevated plus-maze were assessed following intra-septal or intra-amygalar microinfusions of 1) SST (1.5 μg per hemisphere), 2) the highly selective sst2 receptor antagonist PRL2903 (1.5 μg per hemisphere), or 3) the combination of SST and PRL2903 (each 1.5 μg per hemisphere). Antagonism of the anxiolytic effects of SST in the plus-maze by PRL2903 should result in open-arm exploration that is equivalent to that of 4) vehicle-injected control rats. Both intra-septal and intra-amygdalar microinfusions of SST produced anxiolytic effects in the elevated plus-maze, consistent with results found previously after ICV microinfusions (see Engin et al., 2008; Engin and Treit, 2009; Yeung et al., 2011). More importantly, infusion of PRL2903 completely reversed the anxiolytic effects of SST in both the amygdala and the septum. These results show that somatostatin's anxiolytic effects are mediated by sst2 receptors contained in the amygdala and septum of the rat brain.
机译：生长抑素（SST）是具有两种生物同工型（SST14和SST28）和五种SST受体亚型（sst1-5）的多肽。它们一起介导了许多神经和激素功能。最近，我们发现脑室内（ICV），杏仁核和隔隔内SST14，SST28的微输注以及选择性sst2受体激动剂L-779976在升高的迷宫中都产生了类似抗焦虑的作用，这是一种广泛使用的动物焦虑模型。然而，尚未最终确定这些抗焦虑样作用的受体特异性。因此，在隔壁内或杏仁内微滴注1）SST（每半球1.5μg），2）高度选择性sst2受体拮抗剂PRL2903（每半球1.5μg）后，评估SST在升高的迷宫中的抗焦虑作用。或3）SST和PRL2903的组合（每个半球1.5μg）。 PRL2903对迷宫迷宫药中SST的抗焦虑作用的拮抗作用应导致张开双臂的探索，其等效于4）媒介物注射的对照大鼠。 SST的隔壁内和杏仁内微输注均在升高的迷宫中产生抗焦虑作用，这与先前在ICV微输注后发现的结果一致（参见Engin等，2008; Engin和Treit，2009; Yeung等，2011）。 ）。更重要的是，输注PRL2903可以完全逆转杏仁核和隔膜中SST的抗焦虑作用。这些结果表明，生长抑素的抗焦虑作用是由大鼠大脑的杏仁核和中隔中所含的sst2受体介导的。

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