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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Involvement of PKA, CaMKII, PKC, MAPK/ERK and PI3K in the acute antidepressant-like effect of ferulic acid in the tail suspension test
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Involvement of PKA, CaMKII, PKC, MAPK/ERK and PI3K in the acute antidepressant-like effect of ferulic acid in the tail suspension test

机译：PKA，CaMKII，PKC，MAPK / ERK和PI3K参与尾部悬浮试验中阿魏酸的急性抗抑郁样作用

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摘要

Ferulic acid (FA, 4-hydroxy-3-methoxycinnamic acid) is a phytochemical compound naturally present in several plants and foods that is approved as an antioxidant additive and food preservative. It exerts a beneficial action in chronic mild stress-induced depressive-like behavior and produces an acute antidepressant-like effect in the tail suspension test (TST) through the activation of the serotonergic system. This study was aimed at investigating the possible involvement of signaling pathways in the antidepressant-like effect of acute and oral administration of FA, in the TST in mice. The anti-immobility effect of orally administered FA (0.01 mg/kg, p.o.) was prevented by pretreatment of mice with H-89 (1 μg/site, i.c.v., an inhibitor of PKA), KN-62 (1 μg/site, i.c.v., an inhibitor of CaMKII), GF109203X (5 ng/site, i.c.v., an inhibitor of PKC), U0126 (5 μg/site, i.c.v., an inhibitor of MAPK/ERK) or LY294002 (10 nmol/site, i.c.v., an inhibitor of PI3K), all involved with neurotrophic signaling pathways. The results demonstrated that FA exerts antidepressant-like effect in the TST in mice, through the activation of signaling pathways related to neuroplasticity, neurogenesis and cell survival.
机译：阿魏酸（FA，4-羟基-3-甲氧基肉桂酸）是一种植物化学化合物，天然存在于多种植物和食品中，被批准用作抗氧化剂和食品防腐剂。它在慢性轻度应激诱导的抑郁样行为中发挥有益作用，并通过激活血清素能系统在尾部悬吊试验（TST）中产生急性抗抑郁样作用。这项研究旨在调查信号通路可能在小鼠的TST中参与FA的急性和口服抗抑郁药样作用。通过用H-89（1μg/位，icv，PKA的抑制剂），KN-62（1μg/位， icv，CaMKII抑制剂），GF109203X（5 ng /位，icv，PKC抑制剂），U0126（5μg/位，icv，MAPK / ERK抑制剂）或LY294002（10 nmol /位，icv， PI3K抑制剂），都与神经营养信号通路有关。结果表明，FA通过激活与神经可塑性，神经发生和细胞存活有关的信号通路，在小鼠的TST中发挥抗抑郁样作用。

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