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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Experimental hypertension induced vascular dementia: Pharmacological, biochemical and behavioral recuperation by angiotensin receptor blocker and acetylcholinesterase inhibitor
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Experimental hypertension induced vascular dementia: Pharmacological, biochemical and behavioral recuperation by angiotensin receptor blocker and acetylcholinesterase inhibitor

机译：实验性高血压诱发的血管性痴呆：血管紧张素受体阻滞剂和乙酰胆碱酯酶抑制剂的药理，生化和行为恢复

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Involvement of vascular pathology has been suggested in hypertension as well as vascular dementia (VaD), which also have a very high degree of co-occurrence in ageing population. We have recently reported that experimental diabetes as well as hyperhomocystenemia induces VaD. In the present research work, for the first time we are reporting the genesis of VaD by deoxycorticosterone acetate (DOCA)-salt induced experimental hypertension. Furthermore, we have also investigated the beneficial effect of telmisartan, an angiotensin II type 1 receptor blocker (ARB) and donepezil, an acetylcholinesterase inhibitor (AChEI), on DOCA-salt hypertension induced VaD in rats. DOCA-salt hypertensive rats performed poorly on Morris water maze, reflecting impairment in their learning and memory. Furthermore, DOCA-salt treatment has shown a significant impairment of vascular endothelial function (DOCA attenuated acetylcholine induced endothelium dependent relaxation), with a significant reduction in serum nitriteitrate levels, along with increased aortic, serum and brain oxidative stress levels (aortic superoxide anion, serum and brain thiobarbituric acid reactive species, brain glutathione) and brain acetylcholinesterase activity. Treatments of telmisartan as well as donepezil significantly attenuated DOCA-salt hypertension induced learning and memory deficits, endothelial dysfunction, and changes in various biochemical parameters. It may be concluded that DOCA-salt hypertension induces VaD in rats. ARBs and AChEIs may be considered as potential pharmacological agents for the management of hypertension induced VaD.
机译：高血压和血管性痴呆（VaD）已被认为涉及血管病理，在老龄化人群中也具有很高的共发率。我们最近报道了实验性糖尿病以及高同型半胱氨酸血症可诱发VaD。在目前的研究工作中，我们首次报道乙酸脱氧皮质酮盐（DOCA）-盐诱导的实验性高血压的VaD的发生。此外，我们还研究了替米沙坦（一种血管紧张素II型1受体阻滞剂（ARB）和多奈哌齐（一种乙酰胆碱酯酶抑制剂）（AChEI））对大鼠DOCA-盐高血压诱发的VaD的有益作用。 DOCA盐高血压大鼠在莫里斯水迷宫上的表现较差，反映出其学习和记忆能力受损。此外，DOCA盐治疗已显示血管内皮功能显着受损（DOCA减弱了乙酰胆碱引起的内皮依赖性舒张），血清亚硝酸盐/硝酸盐水平显着降低，主动脉，血清和脑部氧化应激水平升高（主动脉超氧化物）阴离子，血清和脑中的硫代巴比妥酸反应物种，脑谷胱甘肽）和脑乙酰胆碱酯酶活性。替米沙坦和多奈哌齐的治疗显着减轻了DOCA-盐高血压引起的学习和记忆障碍，内皮功能障碍以及各种生化参数的变化。可以得出结论，DOCA盐高血压可诱导大鼠中的VaD。 ARB和AChEIs可能被视为治疗高血压诱发的VaD的潜在药理药物。

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