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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Increases in anxiety-like behavior induced by acute stress are reversed by ethanol in adolescent but not adult rats
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Increases in anxiety-like behavior induced by acute stress are reversed by ethanol in adolescent but not adult rats

机译：乙醇可逆转由急性应激引起的焦虑样行为的增加，但在成年大鼠中则无此作用

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Repeated exposure to stressors has been found to increase anxiety-like behavior in laboratory rodents, with the social anxiety induced by repeated restraint being extremely sensitive to anxiolytic effects of ethanol in both adolescent and adult rats. No studies, however, have compared social anxiogenic effects of acute stress or the capacity of ethanol to reverse this anxiety in adolescent and adult animals. Therefore, the present study was designed to investigate whether adolescent [postnatal day (P35)] Sprague-Dawley rats differ from their adult counterparts (P70) in the impact of acute restraint stress on social anxiety and in their sensitivity to the social anxiolytic effects of ethanol. Animals were restrained for 90 min, followed by examination of stress- and ethanol-induced (0, 0.25, 0.5, 0.75, and 1 g/kg) alterations in social behavior using a modified social interaction test in a familiar environment. Acute restraint stress increased anxiety, as indexed by reduced levels of social investigation at both ages, and decreased social preference among adolescents. These increases in anxiety were dramatically reversed among adolescents by acute ethanol. No anxiolytic-like effects of ethanol emerged following restraint stress in adults. The social suppression seen in response to higher doses of ethanol was reversed by restraint stress in animals of both ages. To the extent that these data are applicable to humans, the results of the present study provide some experimental evidence that stressful life events may increase the attractiveness of alcohol as an anxiolytic agent for adolescents.
机译：已经发现，反复暴露于应激源会增加实验室啮齿动物的焦虑样行为，反复约束引起的社交焦虑对青少年和成年大鼠乙醇的抗焦虑作用极为敏感。然而，尚无研究比较急性应激对社会焦虑的影响或乙醇逆转青少年和成年动物焦虑的能力。因此，本研究旨在调查青春期[产后一天（P35）] Sprague-Dawley大鼠是否与成年大鼠（P70）在急性束缚应激对社交焦虑的影响以及它们对APS的社交抗焦虑作用的敏感性方面有所不同。乙醇。将动物约束90分钟，然后使用改良的社交互动测试在熟悉的环境中检查压力和乙醇诱导的社交行为（0、0.25、0.5、0.75和1 g / kg）的变化。急性束缚压力增加了焦虑，这是由两个年龄段的社会调查水平降低所指示的，以及青少年的社会偏好降低。在青少年中，这些急性焦虑症被急性乙醇逆转。在成年人约束压力后，没有出现类似抗焦虑药的作用。在两个年龄段的动物中，束缚压力都可以逆转对更高剂量乙醇的反应所产生的社会抑制。就这些数据适用于人类的程度而言，本研究的结果提供了一些实验证据，表明紧张的生活事件可能会增加酒精作为青少年抗焦虑药的吸引力。

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