• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Activation of amygdalar metabotropic glutamate receptors modulates anxiety, and risk assessment behaviors in ovariectomized estradiol-treated female rats
【24h】

Activation of amygdalar metabotropic glutamate receptors modulates anxiety, and risk assessment behaviors in ovariectomized estradiol-treated female rats

机译：扁桃体代谢型谷氨酸受体的激活调节焦虑，并在卵巢切除雌二醇治疗的雌性大鼠中进行风险评估行为

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Anxiety disorders are more prevalent in females than males. The underlying reasons for this gender difference are unknown. Metabotropic glutamate receptors (mGluRs) have been linked to anxiety and it has been shown that interaction between estrogen receptors and mGluRs modulate sexual receptivity in rats. We investigated the role of mGluRs in anxiety-related behaviors in ovariectomized female rats with (OVX + EB) or without (OVX) estradiol implants. We centrally infused (s)-3,5-dihydroxyphenylglycine (DHPG), a group I mGluR agonist, into the basolateral amygdala (BLA) of OVX + EB and OVX rats at 0.1 and 1.0 μM. Male rats that normally have low estradiol levels were used to compare with OVX rats. Generalized anxiety, explorative activity and detection and analysis of threat were analyzed in the elevated plus maze (EPM) and risk assessment behaviors (RABs). DHPG (1.0 μM) increased the percentage of time spent in- and entries into- the open arms in OVX + EB, but not in OVX or male rats. Flat-back approaches and stretch-attend postures, two RABs, were significantly reduced by DHPG (0.1 and 1.0 μM) in OVX + EB rats only. DHPG did not modulate rearing and freezing, behaviors related to exploration and fear-like behavior, respectively. However, DHPG (1.0 μM) increased head dipping and decreased grooming behaviors in OVX rats, suggesting a weak explorative modulation. The effects of DHPG observed in OVX + EB, were blocked by 50 μM of (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA), a mGluR1 antagonist. AIDA and/or estradiol did not modulate anxiety and or RABs. Our results show that intra-BLA infusion of DHPG exerts an anxiolytic-like effect in OVX + EB, but not in OVX or male rats. This effect seems to depend upon mGluR1 subtype activation. Our findings led us to suggest that the effects observed in OVX + EB rats might be due to an interaction at the membrane level of estrogen receptors with mGlu1 within the BLA.
机译：焦虑症在女性中比男性更为普遍。这种性别差异的根本原因尚不清楚。代谢型谷氨酸受体（mGluRs）与焦虑症有关，并且已显示雌激素受体和mGluRs之间的相互作用调节大鼠的性接受能力。我们调查了在（OVX + EB）或没有（OVX）雌二醇植入的卵巢切除雌性大鼠中，mGluRs在焦虑相关行为中的作用。我们以0.1和1.0μM的浓度将I型mGluR激动剂（s）-3,5-二羟基苯基甘氨酸（DHPG）集中注入到OVX + EB和OVX大鼠的基底外侧杏仁核（BLA）中。通常将雌二醇水平低的雄性大鼠与OVX大鼠进行比较。在高架迷宫（EPM）和风险评估行为（RAB）中分析了广泛性焦虑，探索性活动以及威胁的检测和分析。 DHPG（1.0μM）增加了在OVX + EB中进入和进入开放臂的时间百分比，但没有增加OVX或雄性大鼠的时间。仅OVX + EB大鼠中的DHPG（0.1和1.0μM）显着降低了平躺方法和伸展运动姿势（两个RAB）。 DHPG并没有调节与探索和恐惧样行为相关的饲养和冻结行为。然而，DHPG（1.0μM）增加了OVX大鼠的头部浸入度并降低了修饰行为，这表明其探索性调节作用较弱。在OVX + EB中观察到的DHPG的作用被mGluR1拮抗剂（RS）-1-氨基茚满-1,5-二羧酸（AIDA）阻断了。 AIDA和/或雌二醇不能调节焦虑和/或RAB。我们的结果表明，在DHX的BLA内输注在OVX + EB中表现出抗焦虑样作用，但在OVX或雄性大鼠中却没有。这种作用似乎取决于mGluR1亚型的激活。我们的发现使我们建议在OVX + EB大鼠中观察到的影响可能是由于BLA中雌激素受体的膜水平与mGlu1相互作用所致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号